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Gene

ROBO2

roundabout guidance receptor 2

Summary

Cytogenetic location
3p12.3
Coordinates
Chromosome 3: 77,040,099–77,649,964 (GRCh38)
Exons
28 exons across 609.9 kb
Protein
1,473 amino acids
Also known as
KIAA1568
MANE Select transcript
ENST00000696593.1NM_001395656.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Anomalies of the Kidney and Urinary Tract

    • Vesicoureteral Reflux

      Backward flow of urine from the bladder towards the kidneys, which can run in families and increases the risk of kidney infection and scarring.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing can prompt earlier evaluation of urinary infections in the person and their children.

How ROBO2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 3, with a bracket where ROBO2 sits. ROBO2 and 0 genes near it on chromosome 3, from 76,430,233 to 78,259,830.Chromosome 33p12.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2976.5 Mb77 Mb77.5 Mb78 MbROBO2: 77,040,099–77,649,964, forward strandROBO2Diagram of ROBO2: 28 exons on the forward strand of chromosome 3Exon 1: 77,040,099–77,040,846, 748 basesExon 2: 77,098,014–77,098,340, 327 basesExon 3: 77,477,414–77,477,571, 158 basesExon 4: 77,481,099–77,481,219, 121 basesExon 5: 77,493,244–77,493,382, 139 basesExon 6: 77,522,775–77,522,902, 128 basesExon 7: 77,527,403–77,527,414, 12 basesExon 8: 77,546,338–77,546,462, 125 basesExon 9: 77,550,818–77,550,989, 172 basesExon 10: 77,557,944–77,558,149, 206 basesExon 11: 77,562,651–77,562,732, 82 basesExon 12: 77,563,167–77,563,329, 163 basesExon 13: 77,564,954–77,565,120, 167 basesExon 14: 77,568,313–77,568,434, 122 basesExon 15: 77,574,499–77,574,730, 232 basesExon 16: 77,577,490–77,577,614, 125 basesExon 17: 77,579,947–77,580,118, 172 basesExon 18: 77,588,751–77,588,933, 183 basesExon 19: 77,595,142–77,595,184, 43 basesExon 20: 77,596,623–77,596,750, 128 basesExon 21: 77,602,210–77,602,491, 282 basesExon 22: 77,607,798–77,607,954, 157 basesExon 23: 77,617,513–77,617,773, 261 basesExon 24: 77,622,227–77,622,432, 206 basesExon 25: 77,634,870–77,635,043, 174 basesExon 26: 77,642,671–77,642,943, 273 basesExon 27: 77,644,704–77,644,904, 201 basesExon 28: 77,646,054–77,649,964, 3,911 bases11020285′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9 kb of the gene's 609.9 kb; 4,422 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ROBO2 gene: roundabout guidance receptor 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/robo2

Vancouver

Dante Labs. ROBO2 gene: roundabout guidance receptor 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/robo2

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