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Gene

TSEN34

tRNA splicing endonuclease subunit 34

Summary

Cytogenetic location
19q13.42
Coordinates
Chromosome 19: 54,191,308–54,194,532 (GRCh38)
Exons
4 exons across 3.2 kb
Protein
310 amino acids
Also known as
SEN34, SEN34L
Previous symbols
LENG5
MANE Select transcript
ENST00000396388.3NM_001077446.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TSEN34 yet. The test sequences your whole genome, so your data includes it all the same.

How TSEN34 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where TSEN34 sits. TSEN34 and 33 genes near it on chromosome 19, from 53,692,920 to 54,692,919.Chromosome 1919q13.42p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4353.8 Mb54 Mb54.2 Mb54.4 Mb54.6 MbNLRP12: 53,792,139–53,824,403, reverse strandNLRP12MYADM: 53,864,763–53,878,125, forward strandMYADMPRKCG: 53,879,190–53,907,652, forward strandPRKCGCACNG7: 53,909,264–53,943,950, forward strandCACNG7CACNG8: 53,962,937–53,990,215, forward strandCACNG8CACNG6: 53,991,605–54,012,670, forward strandCACNG6VSTM1: 54,040,825–54,063,959, reverse strandVSTM1TARM1: 54,069,895–54,081,365, reverse strandTARM1OSCAR: 54,094,668–54,102,692, reverse strandOSCARNDUFA3: 54,102,728–54,111,522, forward strandNDUFA3TFPT: 54,107,015–54,115,666, reverse strandTFPTPRPF31: 54,115,410–54,131,719, forward strandCNOT3: 54,137,710–54,155,708, forward strandLENG1: 54,155,161–54,159,760, reverse strandLENG1TMC4: 54,160,095–54,173,250, reverse strandTMC4MBOAT7: 54,173,412–54,189,882, reverse strandMBOAT7TSEN34: 54,191,308–54,194,532, forward strandTSEN34RPS9: 54,200,466–54,249,003, forward strandRPS9LILRB3: 54,215,940–54,223,506, reverse strandLILRB3LILRA6: 54,236,590–54,242,820, reverse strandLILRB5: 54,249,421–54,257,339, reverse strandLILRB5LILRB2: 54,273,812–54,281,184, reverse strandLILRA5: 54,307,037–54,313,177, reverse strandLILRA5LILRA4: 54,333,185–54,339,162, reverse strandLILRA4LAIR1: 54,351,384–54,370,558, reverse strandLAIR1TTYH1: 54,415,219–54,436,904, forward strandTTYH1LENG8: 54,449,157–54,462,022, forward strandLENG8LENG9: 54,461,732–54,463,778, reverse strandLENG9CDC42EP5: 54,465,026–54,473,316, reverse strandCDC42EP5LAIR2: 54,497,879–54,510,694, forward strandLAIR2LILRA2: 54,572,920–54,590,287, forward strandLILRA2LILRA1: 54,593,582–54,603,259, forward strandLILRA1LILRB1: 54,616,309–54,638,022, forward strandLILRB1LILRB4: 54,643,889–54,670,531, forward strandLILRB4Diagram of TSEN34: 4 exons on the forward strand of chromosome 19Exon 4: 1 known disease-causing siteExon 1: 54,191,308–54,191,607, 300 basesExon 2: 54,191,721–54,191,964, 244 basesExon 3: 54,192,116–54,192,373, 258 basesExon 4: 54,193,175–54,194,532, 1,358 bases12345′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 3.2 kb; 933 of those bases code for the protein.

How a genome test reads TSEN34

1

position in TSEN34 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.2 kb of TSEN34, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TSEN34 gene: tRNA splicing endonuclease subunit 34. Retrieved 17 October 2026, from https://dantelabs.com/genes/tsen34

Vancouver

Dante Labs. TSEN34 gene: tRNA splicing endonuclease subunit 34 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tsen34

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