Traits

Traits linked to FRYL

FRY like transcription coactivator

The Human Phenotype Ontology links 70 traits to FRYL, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormal social development	Always
Anxiety	Always
Attention deficit	Always
Borderline personality disorder	Always
Delayed speech and language development	Always
Depression	Always
Difficulty sleeping	Always
Global developmental delay	Always
Intellectual disability	Always
Tic disorder	Always
Autism	Often (30–79%)
Generalized-onset seizure	Often (30–79%)
Seizure affecting one half of brain	Often (30–79%)
Cortical dysplasia	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Hippocampal malrotation	Sometimes (5–29%)
Thin corpus callosum	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Downward slanting of the opening between the eyelids	Always
Upward slanting of the opening between the eyelids	Always
Abnormally small head	Sometimes (5–29%)
Almond shaped eyes	Sometimes (5–29%)
Depressed nasal bridge	Sometimes (5–29%)
Eye folds	Sometimes (5–29%)
Frontal bossing	Sometimes (5–29%)
Long face	Sometimes (5–29%)
Long philtrum	Sometimes (5–29%)
Narrow forehead	Sometimes (5–29%)
Nasal tip, upturned	Sometimes (5–29%)
Pit in front of the ear	Sometimes (5–29%)
Receding chin	Sometimes (5–29%)
Short nose	Sometimes (5–29%)
Short philtrum	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Absent spleen	Always
Increased blood pressure in blood vessels of lungs	Always
Multiple small spleens	Always
Patent foramen ovale	Often (30–79%)
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Heart tip and four chambers point towards right side of body	Sometimes (5–29%)
Hole in center of heart	Sometimes (5–29%)
Hole in heart wall separating two lower heart chambers	Sometimes (5–29%)
Interrupted aortic arch	Sometimes (5–29%)
Narrowing of aortic valve	Sometimes (5–29%)
Narrowing of peripheral lung artery	Sometimes (5–29%)
Narrowing of pulmonic valve	Sometimes (5–29%)
Patent ductus arteriosus	Sometimes (5–29%)
Tetralogy of Fallot	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Chordee	Always
Horseshoe kidney	Always
Hydrocele testis	Always
Hypospadias	Always
Loss of bladder control	Always
Undescended testes	Always

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Cancer of lymphatic system	Always
Low platelet count	Always
Intraventricular hemorrhage	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Jejunal atresia	Sometimes (5–29%)
Microcolon	Sometimes (5–29%)
Midline liver	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Always
Ears rotated toward back of head	Sometimes (5–29%)
Low-set ears	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Decreased body weight	Often (30–79%)
Small for gestational age	Often (30–79%)
Short stature	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Deeply set eye	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Atypical nail growth	Sometimes (5–29%)
Spinal dimple	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Pigeon chest	Always
Low muscle tone	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FRYL and how often each is seen. Find out more at hpo.jax.org.

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