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Gene

HGS

hepatocyte growth factor-regulated tyrosine kinase substrate

Summary

Cytogenetic location
17q25.3
Coordinates
Chromosome 17: 81,684,011–81,702,121 (GRCh38)
Exons
22 exons across 18.1 kb
Protein
777 amino acids
Also known as
Hrs, ZFYVE8, Vps27
MANE Select transcript
ENST00000329138.9NM_004712.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HGS yet. The test sequences your whole genome, so your data includes it all the same.

How HGS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 17, with a bracket where HGS sits. HGS and 41 genes near it on chromosome 17, from 81,193,066 to 82,193,065.Chromosome 1717q25.3p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.381.2 Mb81.4 Mb81.6 Mb81.8 Mb82 MbCEP131: 81,189,583–81,223,014, reverse strandCEP131TEPSIN: 81,228,277–81,239,095, reverse strandTEPSINNDUFAF8: 81,239,305–81,241,310, forward strandNDUFAF8SLC38A10: 81,244,811–81,295,567, reverse strandSLC38A10BAHCC1: 81,395,450–81,466,331, forward strandBAHCC1ACTG1: 81,509,413–81,523,847, reverse strandACTG1FSCN2: 81,528,372–81,542,415, forward strandFSCN2FAAP100: 81,539,885–81,553,961, reverse strandFAAP100NPLOC4: 81,556,887–81,648,465, reverse strandNPLOC4TSPAN10: 81,637,171–81,648,754, forward strandPDE6G: 81,650,459–81,663,112, reverse strandOXLD1: 81,665,033–81,666,635, reverse strandOXLD1CCDC137: 81,666,698–81,673,904, forward strandARL16: 81,681,160–81,683,797, reverse strandARL16HGS: 81,684,011–81,702,121, forward strandHGSMRPL12: 81,703,357–81,711,112, forward strandMRPL12: 81,703,371–81,720,539, forward strandSLC25A10: 81,711,951–81,721,969, forward strandGCGR: 81,803,105–81,814,023, forward strandGCGRMCRIP1: 81,821,790–81,833,302, reverse strandMCRIP1PPP1R27: 81,833,488–81,835,056, reverse strandPPP1R27P4HB: 81,843,158–81,860,856, reverse strandP4HBARHGDIA: 81,867,719–81,871,378, reverse strandARHGDIAALYREF: 81,887,830–81,891,835, reverse strandALYREFANAPC11: 81,890,669–81,900,991, forward strandNPB: 81,900,745–81,902,905, forward strandNPBPCYT2: 81,900,958–81,911,507, reverse strandSIRT7: 81,911,939–81,921,323, reverse strandMAFG: 81,918,270–81,927,769, reverse strandPYCR1: 81,932,378–81,942,412, reverse strandPYCR1MYADML2: 81,939,645–81,947,233, reverse strandNOTUM: 81,952,507–81,963,328, reverse strandNOTUMASPSCR1: 81,976,807–82,018,698, forward strandASPSCR1CENPX: 82,018,590–82,024,107, reverse strandCENPXLRRC45: 82,023,269–82,031,153, forward strandLRRC45RAC3: 82,031,192–82,034,218, forward strandRAC3DCXR: 82,035,136–82,037,777, reverse strandRFNG: 82,047,902–82,051,871, reverse strandGPS1: 82,050,691–82,058,063, forward strandDUS1L: 82,057,506–82,066,206, reverse strandFASN: 82,076,900–82,098,294, reverse strandFASNCCDC57: 82,101,458–82,212,885, reverse strandCCDC57Diagram of HGS: 22 exons on the forward strand of chromosome 17Exon 1: 81,684,011–81,684,103, 93 basesExon 2: 81,685,605–81,685,689, 85 basesExon 3: 81,686,312–81,686,387, 76 basesExon 4: 81,687,003–81,687,095, 93 basesExon 5: 81,688,704–81,688,827, 124 basesExon 6: 81,690,182–81,690,234, 53 basesExon 7: 81,690,674–81,690,742, 69 basesExon 8: 81,691,447–81,691,571, 125 basesExon 9: 81,693,503–81,693,581, 79 basesExon 10: 81,693,654–81,693,752, 99 basesExon 11: 81,693,870–81,693,965, 96 basesExon 12: 81,694,815–81,694,853, 39 basesExon 13: 81,694,924–81,695,067, 144 basesExon 14: 81,695,164–81,695,223, 60 basesExon 15: 81,695,786–81,695,999, 214 basesExon 16: 81,696,357–81,696,529, 173 basesExon 17: 81,696,607–81,696,747, 141 basesExon 18: 81,696,824–81,696,998, 175 basesExon 19: 81,700,467–81,700,600, 134 basesExon 20: 81,700,695–81,700,814, 120 basesExon 21: 81,701,045–81,701,131, 87 basesExon 22: 81,701,508–81,702,121, 614 bases15101520225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 18.1 kb; 2,334 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). HGS gene: hepatocyte growth factor-regulated tyrosine kinase substrate. Retrieved 17 October 2026, from https://dantelabs.com/genes/hgs

Vancouver

Dante Labs. HGS gene: hepatocyte growth factor-regulated tyrosine kinase substrate [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hgs

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