Traits

Traits linked to ANLN

anillin, actin binding protein

The Human Phenotype Ontology links 18 traits to ANLN, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the genitourinary system

Trait	How often it is seen
Focal segmental glomerulosclerosis	Always
Stage 5 chronic kidney disease	Always
Chronic kidney disease	Often (30–79%)
Diffuse mesangial sclerosis	Sometimes (5–29%)
Minimal change glomerulonephritis	Sometimes (5–29%)
Nephrotic syndrome	Not recorded

Laboratory abnormality

Trait	How often it is seen
High urine protein levels	Always
Fluid retention	Very often (80–99%)
Fever	Sometimes (5–29%)
Foamy urine	Sometimes (5–29%)
Low albumin	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Headache	Sometimes (5–29%)
Irritability	Sometimes (5–29%)
Abnormality of the nervous system	Rarely (1–4%)

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Sometimes (5–29%)
Peritonitis	Rarely (1–4%)

Abnormality of head or neck

Trait	How often it is seen
Periorbital edema	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Respiratory tract infection	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ANLN and how often each is seen. Find out more at hpo.jax.org.

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