Trait

Hypoinsulinemia

A decreased concentration of insulin in the blood.

Body system: Abnormality of the endocrine system

This page as data

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library(jsonlite)

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page <- fromJSON(url)
page$trait$name

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22 genes linked to Hypoinsulinemia

Changes in these genes cause rare conditions in which Hypoinsulinemia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AKT2AKT serine/threonine kinase 2	Always	In 1 condition
PAX4paired box 4	Always	In 2 conditions
PCSK1proprotein convertase subtilisin/kexin type 1	Always	In 1 condition
ABCC8ATP binding cassette subfamily C member 8	Very often (80–99%)	In 2 conditions
HYMAIhydatidiform mole associated and imprinted	Very often (80–99%)	In 1 condition
KCNJ11potassium inwardly rectifying channel subfamily J member 11	Very often (80–99%)	In 2 conditions
PLAGL1PLAG1 like zinc finger 1	Very often (80–99%)	In 1 condition
ZFP57ZFP57 zinc finger protein	Very often (80–99%)	In 1 condition
APPL1adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Often (30–79%)	In 1 condition
BLKBLK proto-oncogene, Src family tyrosine kinase	Often (30–79%)	In 1 condition
CELcarboxyl ester lipase	Often (30–79%)	In 1 condition
GCKglucokinase	Often (30–79%)	In 1 condition
HNF1AHNF1 homeobox A	Often (30–79%)	In 1 condition
HNF4Ahepatocyte nuclear factor 4 alpha	Often (30–79%)	In 1 condition
INSinsulin	Often (30–79%)	In 1 condition
KLF11KLF transcription factor 11	Often (30–79%)	In 1 condition
NEUROD1neuronal differentiation 1	Often (30–79%)	In 1 condition
PDX1pancreatic and duodenal homeobox 1	Often (30–79%)	In 1 condition
DMXL2Dmx like 2	Sometimes (5–29%)	In 1 condition
RNF125ring finger protein 125	Sometimes (5–29%)	In 1 condition
NAB2NGFI-A binding protein 2	Rarely (1–4%)	In 1 condition
STAT6signal transducer and activator of transcription 6	Rarely (1–4%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal circulating insulin concentration

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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