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Gene

PLD3

phospholipase D family member 3

Summary

Cytogenetic location
19q13.2
Coordinates
Chromosome 19: 40,348,695–40,378,485 (GRCh38)
Exons
13 exons across 29.8 kb
Protein
490 amino acids
Also known as
HU-K4
MANE Select transcript
ENST00000409735.9NM_012268.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PLD3 yet. The test sequences your whole genome, so your data includes it all the same.

How PLD3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 19, with a bracket where PLD3 sits. PLD3 and 30 genes near it on chromosome 19, from 39,863,590 to 40,863,589.Chromosome 1919q13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4340 Mb40.2 Mb40.4 Mb40.6 Mb40.8 MbFCGBP: 39,863,323–39,934,634, reverse strandFCGBPPSMC4: 39,970,990–39,982,814, forward strandPSMC4ZNF546: 39,984,134–40,021,038, forward strandZNF546ZNF780B: 40,023,079–40,056,305, reverse strandZNF780BZNF780A: 40,069,152–40,091,140, reverse strandZNF780AMAP3K10: 40,191,412–40,215,579, forward strandMAP3K10TTC9B: 40,216,058–40,218,521, reverse strandTTC9BCCNP: 40,222,208–40,226,697, reverse strandCCNPAKT2: 40,230,317–40,285,536, reverse strandAKT2C19orf47: 40,294,427–40,348,547, reverse strandC19orf47PLD3: 40,348,695–40,378,485, forward strandPLD3HIPK4: 40,379,271–40,390,181, reverse strandHIPK4PRX: 40,393,764–40,415,070, reverse strandPRXSERTAD1: 40,421,589–40,426,001, reverse strandSERTAD1SERTAD3: 40,440,642–40,445,114, reverse strandSERTAD3BLVRB: 40,446,758–40,465,826, reverse strandBLVRBSPTBN4: 40,466,241–40,576,464, forward strandSPTBN4SHKBP1: 40,576,844–40,591,399, forward strandSHKBP1LTBP4: 40,592,883–40,629,821, forward strandLTBP4NUMBL: 40,665,905–40,690,972, reverse strandNUMBLCOQ8B: 40,691,514–40,725,784, reverse strandCOQ8BITPKC: 40,716,964–40,740,860, forward strandITPKCACTMAP: 40,740,856–40,751,813, reverse strandACTMAPSNRPA: 40,750,585–40,765,393, forward strandSNRPAMIA: 40,768,997–40,777,490, forward strandMIAMIA-RAB4B: 40,771,648–40,796,943, forward strandRAB4B: 40,778,191–40,798,690, forward strandRAB4BRAB4B-EGLN2: 40,778,242–40,808,418, forward strandEGLN2: 40,798,996–40,857,708, forward strandEGLN2: 40,801,297–40,898,282, forward strandCYP2A6: 40,841,915–40,850,493, reverse strandCYP2A6Diagram of PLD3: 13 exons on the forward strand of chromosome 19Exon 1: 40,348,695–40,348,768, 74 basesExon 2: 40,365,718–40,365,930, 213 basesExon 3: 40,366,419–40,366,510, 92 basesExon 4: 40,366,610–40,366,684, 75 basesExon 5: 40,366,773–40,366,915, 143 basesExon 6: 40,367,696–40,367,879, 184 basesExon 7: 40,369,908–40,370,028, 121 basesExon 8: 40,370,110–40,370,237, 128 basesExon 9: 40,371,673–40,371,873, 201 basesExon 10: 40,374,481–40,374,620, 140 basesExon 11: 40,376,609–40,376,774, 166 basesExon 12: 40,377,786–40,377,885, 100 basesExon 13: 40,377,986–40,378,485, 500 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 29.8 kb; 1,473 of those bases code for the protein.

How a genome test reads PLD3

3

positions in PLD3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 29.8 kb of PLD3, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PLD3 gene: phospholipase D family member 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/pld3

Vancouver

Dante Labs. PLD3 gene: phospholipase D family member 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pld3

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