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Gene

PLEKHG4

pleckstrin homology and RhoGEF domain containing G4

Summary

Cytogenetic location
16q22.1
Coordinates
Chromosome 16: 67,279,532–67,289,480 (GRCh38)
Exons
22 exons across 9.9 kb
Protein
1,191 amino acids
Also known as
DKFZP434I216, ARHGEF44
Previous symbols
SCA4
MANE Select transcript
ENST00000379344.8NM_001129729.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PLEKHG4 yet. The test sequences your whole genome, so your data includes it all the same.

How PLEKHG4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 16, with a bracket where PLEKHG4 sits. PLEKHG4 and 41 genes near it on chromosome 16, from 66,784,506 to 67,784,505.Chromosome 1616q22.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.366.8 Mb67 Mb67.2 Mb67.4 Mb67.6 MbTERB1: 66,754,640–66,801,620, reverse strandTERB1NAE1: 66,802,874–66,873,256, reverse strandNAE1CA7: 66,844,414–66,854,153, forward strandCA7PDP2: 66,878,589–66,895,754, forward strandPDP2CDH16: 66,908,122–66,919,187, reverse strandCDH16RRAD: 66,921,682–66,926,308, reverse strandRRADCIAO2B: 66,931,938–66,934,929, reverse strandCIAO2BCES2: 66,934,433–66,945,096, forward strandCES2CES3: 66,961,219–66,975,162, forward strandCES3CES4A: 66,988,574–67,010,417, forward strandCES4ACBFB: 67,028,984–67,101,058, forward strandCBFBPHAF1: 67,109,941–67,148,544, forward strandPHAF1B3GNT9: 67,142,023–67,151,260, reverse strandTRADD: 67,153,969–67,163,760, reverse strandFBXL8: 67,159,932–67,164,570, forward strand: 67,163,385–67,165,815, forward strandHSF4: 67,164,681–67,169,945, forward strandHSF4NOL3: 67,170,154–67,176,189, forward strandMATCAP1: 67,175,599–67,184,228, reverse strandEXOC3L1: 67,184,313–67,190,242, reverse strandE2F4: 67,192,117–67,198,919, forward strandE2F4ELMO3: 67,199,105–67,204,029, forward strandELMO3TMEM208: 67,227,103–67,229,281, forward strandTMEM208FHOD1: 67,229,387–67,247,539, reverse strandFHOD1SLC9A5: 67,237,683–67,272,191, forward strandSLC9A5PLEKHG4: 67,279,532–67,289,480, forward strandPLEKHG4KCTD19: 67,289,428–67,326,766, reverse strandKCTD19LRRC36: 67,326,798–67,385,221, forward strandLRRC36TPPP3: 67,389,027–67,393,518, reverse strandTPPP3ZDHHC1: 67,394,152–67,416,833, reverse strandZDHHC1HSD11B2: 67,430,652–67,437,553, forward strandHSD11B2ATP6V0D1: 67,437,523–67,481,227, reverse strandATP6V0D1AGRP: 67,482,571–67,483,552, reverse strandAGRPRIPOR1: 67,518,418–67,546,788, forward strandRIPOR1CTCF: 67,561,831–67,639,189, forward strandCTCFCARMIL2: 67,644,988–67,657,569, forward strandCARMIL2ACD: 67,657,512–67,660,810, reverse strandACDPARD6A: 67,660,350–67,664,266, forward strandPARD6AENKD1: 67,662,945–67,667,954, reverse strandC16orf86: 67,666,802–67,668,757, forward strandGFOD2: 67,674,527–67,719,352, reverse strandRANBP10: 67,723,070–67,806,563, reverse strandRANBP10Diagram of PLEKHG4: 22 exons on the forward strand of chromosome 16Exon 1: 67,279,532–67,279,626, 95 basesExon 2: 67,279,876–67,280,543, 668 basesExon 3: 67,280,711–67,280,806, 96 basesExon 4: 67,280,882–67,281,005, 124 basesExon 5: 67,281,091–67,281,184, 94 basesExon 6: 67,281,567–67,281,644, 78 basesExon 7: 67,281,724–67,281,837, 114 basesExon 8: 67,282,009–67,282,107, 99 basesExon 9: 67,282,201–67,282,349, 149 basesExon 10: 67,282,503–67,282,641, 139 basesExon 11: 67,282,742–67,282,858, 117 basesExon 12: 67,284,275–67,284,457, 183 basesExon 13: 67,284,713–67,285,215, 503 basesExon 14: 67,285,290–67,285,536, 247 basesExon 15: 67,286,274–67,286,363, 90 basesExon 16: 67,286,445–67,286,666, 222 basesExon 17: 67,286,749–67,286,919, 171 basesExon 18: 67,287,000–67,287,177, 178 basesExon 19: 67,287,898–67,288,014, 117 basesExon 20: 67,288,167–67,288,400, 234 basesExon 21: 67,288,489–67,288,604, 116 basesExon 22: 67,288,803–67,289,480, 678 bases12468101214161820225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 9.9 kb; 3,576 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). PLEKHG4 gene: pleckstrin homology and RhoGEF domain containing G4. Retrieved 17 October 2026, from https://dantelabs.com/genes/plekhg4

Vancouver

Dante Labs. PLEKHG4 gene: pleckstrin homology and RhoGEF domain containing G4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/plekhg4

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