Trait
Agyria
A congenital abnormality of the cerebral hemisphere characterized by lack of gyrations (convolutions) of the cerebral cortex. Agyria is defined as cortical regions lacking gyration with sulci great than 3 cm apart and cerebral cortex thicker than 5 mm.
Summary
- Also called
- Agyria diffuse
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test20 genes linked to Agyria
Changes in these genes cause rare conditions in which Agyria is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BAIAP2BAR/IMD domain containing adaptor protein 2 | Always | In 1 condition |
| CDK5cyclin dependent kinase 5 | Always | In 1 condition |
| CRNKL1crooked neck pre-mRNA splicing factor 1 | Always | In 1 condition |
| FKRPfukutin related protein | Always | In 2 conditions |
| FKTNfukutin | Always | In 2 conditions |
| LARGE1LARGE xylosyl- and glucuronyltransferase 1 | Always | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Always | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Always | In 1 condition |
| DAG1dystroglycan 1 | Often (30–79%) | In 2 conditions |
| DCXdoublecortin | Often (30–79%) | In 2 conditions |
| KIF2Akinesin family member 2A | Often (30–79%) | In 1 condition |
| PAFAH1B1platelet activating factor acetylhydrolase 1b regulatory subunit 1 | Often (30–79%) | In 2 conditions |
| TMTC3transmembrane O-mannosyltransferase targeting cadherins 3 | Often (30–79%) | In 1 condition |
| TUBA1Atubulin alpha 1a | Often (30–79%) | In 3 conditions |
| TUBB2Btubulin beta 2B class IIb | Often (30–79%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Often (30–79%) | In 1 condition |
| TUBG1tubulin gamma 1 | Often (30–79%) | In 1 condition |
| CEP85Lcentrosomal protein 85L | Sometimes (5–29%) | In 1 condition |
| POMKprotein O-mannose kinase | Rarely (1–4%) | In 1 condition |
| CRPPACDP-L-ribitol pyrophosphorylase A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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