Skip to content
Use your HSA or FSA funds

Gene

RAD51D

RAD51 paralog D

Summary

Cytogenetic location
17q12
Coordinates
Chromosome 17: 35,092,221–35,119,860 (GRCh38)
Exons
10 exons across 27.6 kb
Protein
328 amino acids
Inheritance
Autosomal dominant
Also known as
R51H3, Trad, HsTRAD
Previous symbols
RAD51L3
MANE Select transcript
ENST00000345365.11NM_002878.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Breast and Ovarian Cancer Genes Beyond BRCA1/2

    • RAD51D-related cancer predispositionAutosomal dominant

      Variants in RAD51D that raise the risk of ovarian cancer and, to a lesser degree, breast cancer.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Removal of the ovaries and fallopian tubes is often considered from the mid-40s to reduce ovarian cancer risk.

    • Familial breast-ovarian cancer susceptibility 4 (RAD51D)Autosomal dominant

      RAD51D-related susceptibility to breast and ovarian cancer.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How RAD51D is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where RAD51D sits. RAD51D and 18 genes near it on chromosome 17, from 34,606,041 to 35,606,040.Chromosome 1717q12p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.334.8 Mb35 Mb35.2 Mb35.4 Mb35.6 MbTMEM132E: 34,579,487–34,639,318, forward strandTMEM132ECCT6B: 34,927,842–34,981,078, reverse strandCCT6BZNF830: 34,961,540–34,963,777, forward strandZNF830LIG3: 34,980,462–35,009,743, forward strandLIG3RFFL: 35,005,990–35,089,899, reverse strandRFFL: 35,011,349–35,121,493, reverse strandRAD51D: 35,092,221–35,119,860, reverse strandRAD51DFNDC8: 35,121,615–35,130,732, forward strandFNDC8NLE1: 35,125,556–35,142,313, reverse strandNLE1UNC45B: 35,146,495–35,189,346, forward strandUNC45BSLC35G3: 35,192,520–35,194,393, reverse strandSLC35G3SLFN5: 35,243,043–35,273,655, forward strandSLFN5SLFN11: 35,350,305–35,373,701, reverse strandSLFN11SLFN12: 35,409,339–35,433,475, reverse strandSLFN12SLFN13: 35,435,096–35,449,766, reverse strandSLFN13SLFN12L: 35,464,249–35,537,770, reverse strandSLFN12LSLFN14: 35,543,985–35,560,819, reverse strandSLFN14PEX12: 35,574,795–35,578,863, reverse strandPEX12AP2B1: 35,578,046–35,726,417, forward strandAP2B1Diagram of RAD51D: 10 exons on the reverse strand of chromosome 17Exon 10: 3 known disease-causing sitesExon 9: 29 known disease-causing sitesExon 8: 12 known disease-causing sitesExon 7: 18 known disease-causing sitesExon 6: 18 known disease-causing sitesExon 5: 20 known disease-causing sitesExon 4: 21 known disease-causing sitesExon 3: 23 known disease-causing sitesExon 2: 8 known disease-causing sitesExon 1: 18 known disease-causing sitesExon 10: 35,092,221–35,101,036, 8,816 basesExon 9: 35,101,201–35,101,365, 165 basesExon 8: 35,103,254–35,103,324, 71 basesExon 7: 35,103,454–35,103,544, 91 basesExon 6: 35,106,386–35,106,481, 96 basesExon 5: 35,106,988–35,107,122, 135 basesExon 4: 35,107,366–35,107,447, 82 basesExon 3: 35,118,501–35,118,619, 119 basesExon 2: 35,119,111–35,119,172, 62 basesExon 1: 35,119,532–35,119,860, 329 bases10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10 kb of the gene's 27.6 kb; 987 of those bases code for the protein.

How a genome test reads RAD51D

217

positions in RAD51D where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 27.6 kb of RAD51D, introns included, not only the 10 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RAD51D gene: RAD51 paralog D. Retrieved 16 October 2026, from https://dantelabs.com/genes/rad51d

Vancouver

Dante Labs. RAD51D gene: RAD51 paralog D [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rad51d

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test