Traits

Traits linked to NEXN

nexilin F-actin binding protein

The Human Phenotype Ontology links 46 traits to NEXN, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal left ventricular function	Always
Apical hypertrabeculation of the left ventricle	Always
Biventricular hypertrophy	Always
Elevated heart rate	Always
Elevated left ventricular end-diastolic diameter	Always
Endocardial fibroelastosis	Always
Enlarged and thickened heart muscle	Always
Increased left ventricular end-diastolic volume	Always
Left atrial enlargement	Always
Left ventricular dilatation	Always
Left ventricular hypertrophy	Always
Moderately reduced left ventricular ejection fraction	Always
Pulmonic regurgitation	Always
Reduced left ventricular ejection fraction	Always
Reduced systolic function	Always
Right atrial enlargement	Always
Severely reduced left ventricular ejection fraction	Always
Stretched and thinned heart muscle	Always
Tricuspid regurgitation	Always
Left ventricular systolic dysfunction	Very often (80–99%)
Abnormal heart rate	Often (30–79%)
Cardiac failure	Often (30–79%)
Enlarged heart	Often (30–79%)
Mitral regurgitation	Often (30–79%)
Quivering upper heart chambers resulting in irregular heartbeat	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Absent end-diastolic umbilical artery flow	Always
Fetal ascites	Always
Fetal pericardial effusion	Always
Fetal pleural effusion	Always
High levels of amniotic fluid	Always
Less than 10 fetal movements in 12 hours	Always

Laboratory abnormality

Trait	How often it is seen
Hydrops fetalis	Always
Nonimmune hydrops fetalis	Always
Fluid around lungs	Often (30–79%)
Fluid retention	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
EMG abnormality	Sometimes (5–29%)
Loss of fat tissue in localized area	Sometimes (5–29%)
Muscle tissue disease	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Accumulation of fluid in the abdomen	Always
Tube feeding	Always

Abnormality of the respiratory system

Trait	How often it is seen
Exertional breathlessness	Often (30–79%)
Orthopnea	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Thromboembolic stroke	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NEXN and how often each is seen. Find out more at hpo.jax.org.

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