Traits

Traits linked to KICS2

KICSTOR subunit 2

The Human Phenotype Ontology links 57 traits to KICS2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Difficulty falling asleep	Always
Difficulty staying asleep	Always
Focal autonomic seizure	Always
Grand mal seizures	Always
Intellectual disability	Always
Intellectual disability, mild	Always
Intellectual disability, severe	Always
IQ between 34 and 49	Always
Nail-biting	Always
Receptive language delay	Always
Abnormality of movement	Often (30–79%)
Absent speech development	Often (30–79%)
Attention deficit	Often (30–79%)
Delayed ability to walk	Often (30–79%)
Delayed speech and language development	Often (30–79%)
Epilepsy	Often (30–79%)
Gliosis	Often (30–79%)
Jerking	Often (30–79%)
Periventricular white matter hyperintensities	Often (30–79%)
Repetitive movements	Often (30–79%)
Speech apraxia	Often (30–79%)
Aggressive behavior	Sometimes (5–29%)
Autism	Sometimes (5–29%)
Difficulty sleeping	Sometimes (5–29%)
Dystonia	Sometimes (5–29%)
Loss of developmental milestones	Sometimes (5–29%)
Paroxysmal bursts of laughter	Sometimes (5–29%)
Self-injurious behavior	Sometimes (5–29%)
Stereotypical hand wringing	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Relatively large head	Always
Deep philtrum	Often (30–79%)
Low hanging columella	Often (30–79%)
Short nose	Often (30–79%)
Short philtrum	Often (30–79%)
Small head present at birth	Often (30–79%)
Wide nasal bridge	Often (30–79%)
Wide nose	Often (30–79%)
Big calvaria	Sometimes (5–29%)
Depressed nasal bridge	Sometimes (5–29%)
Drooling	Sometimes (5–29%)
High palate	Sometimes (5–29%)
Monobrow	Sometimes (5–29%)
Nasal tip, upturned	Sometimes (5–29%)
Prominent forehead	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Esodeviation	Sometimes (5–29%)
Farsightedness	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of little finger	Always
Webbed fingers or toes	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Conductive deafness	Always
Hearing impairment	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Very often (80–99%)
Tired easily	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Decreased body weight	Often (30–79%)
Small for gestational age	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Narrowing of aortic valve	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Vomiting	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KICS2 and how often each is seen. Find out more at hpo.jax.org.

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