Traits

Traits linked to FBXO11

F-box protein 11

The Human Phenotype Ontology links 122 traits to FBXO11, by body system: features seen in people with one of the gene's rare conditions.

FBXO11

Abnormality of head or neck

Trait	How often it is seen
Full lips	Always
Abnormally small head	Sometimes (5–29%)
Bifid uvula	Sometimes (5–29%)
Big calvaria	Sometimes (5–29%)
Big lower jaw	Sometimes (5–29%)
Blepharochalasis	Sometimes (5–29%)
Broad eyebrow	Sometimes (5–29%)
Broad forehead	Sometimes (5–29%)
Broad head shape	Sometimes (5–29%)
Broad nasal tip	Sometimes (5–29%)
Broad opening between the eyelids	Sometimes (5–29%)
Bulbous nose	Sometimes (5–29%)
Cleft lip	Sometimes (5–29%)
Cleft palate	Sometimes (5–29%)
Coarse facial features	Sometimes (5–29%)
Downward slanting of the opening between the eyelids	Sometimes (5–29%)
Drooping lower lip	Sometimes (5–29%)
Early closure of midline skull joint	Sometimes (5–29%)
Eye folds	Sometimes (5–29%)
Flat nose	Sometimes (5–29%)
Frontal bossing	Sometimes (5–29%)
Full cheeks	Sometimes (5–29%)
Full lower lip	Sometimes (5–29%)
Fullness around the eyes	Sometimes (5–29%)
High palate	Sometimes (5–29%)
Highly arched eyebrow	Sometimes (5–29%)
Little lower jaw	Sometimes (5–29%)
Long eyelashes	Sometimes (5–29%)
Long face	Sometimes (5–29%)
Long philtrum	Sometimes (5–29%)
Metopic synostosis	Sometimes (5–29%)
Narrow eyelid opening	Sometimes (5–29%)
Narrow mouth	Sometimes (5–29%)
Nasal tip, upturned	Sometimes (5–29%)
Pit in front of the ear	Sometimes (5–29%)
Pointed chin	Sometimes (5–29%)
Prominent nasal bridge	Sometimes (5–29%)
Prominent nose	Sometimes (5–29%)
Receding chin	Sometimes (5–29%)
Short nose	Sometimes (5–29%)
Short philtrum	Sometimes (5–29%)
Short uvula	Sometimes (5–29%)
Smooth philtrum	Sometimes (5–29%)
Sparse eyebrow	Sometimes (5–29%)
Tented mouth	Sometimes (5–29%)
Thin red part of the upper lip	Sometimes (5–29%)
Tongue tied	Sometimes (5–29%)
Triangular face	Sometimes (5–29%)
Wide mouth	Sometimes (5–29%)
Wide nasal bridge	Sometimes (5–29%)
Asymmetry of the posterior head	Not recorded
Downturned corners of mouth	Not recorded
High forehead	Not recorded

Abnormality of limbs

Trait	How often it is seen
Broad finger	Always
Bilateral camptodactyly	Sometimes (5–29%)
Broad foot	Sometimes (5–29%)
Broad outermost finger bone	Sometimes (5–29%)
Curvature of digit	Sometimes (5–29%)
Deep wrinkles in soles of feet	Sometimes (5–29%)
Dropped arches	Sometimes (5–29%)
Fused toes	Sometimes (5–29%)
Gap between 1st and 2nd toes	Sometimes (5–29%)
Long slender fingers	Sometimes (5–29%)
Outward turned elbows	Sometimes (5–29%)
Short palm	Sometimes (5–29%)
Single transverse palmar crease	Sometimes (5–29%)
Small hand	Sometimes (5–29%)
Tapered finger	Sometimes (5–29%)
Short foot	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Always
Global developmental delay	Always
Intellectual disability	Always
Autism spectrum disorder	Often (30–79%)
Delayed ability to walk	Often (30–79%)
Difficulty falling asleep	Often (30–79%)
Difficulty sleeping	Often (30–79%)
Epilepsy	Often (30–79%)
More active than typical	Often (30–79%)
Fluid-filled cyst in spinal cord	Sometimes (5–29%)
Loss of developmental milestones	Sometimes (5–29%)
Short attention span	Not recorded

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Always
Bulging eye	Sometimes (5–29%)
Duane anomaly	Sometimes (5–29%)
Esodeviation	Sometimes (5–29%)
Farsightedness	Sometimes (5–29%)
Increased size of eyes	Sometimes (5–29%)
Severe near sightedness	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)
Deeply set eye	Not recorded

Abnormality of the ear

Trait	How often it is seen
Large ears	Sometimes (5–29%)
Low-set ears	Sometimes (5–29%)
Prominent ear	Sometimes (5–29%)
Prominent tragus	Sometimes (5–29%)
Recurrent middle ear infection	Sometimes (5–29%)
Ears rotated toward back of head	Not recorded
Small ears	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
Delayed bone maturation	Sometimes (5–29%)
Double-Jointed	Sometimes (5–29%)
Osteopenia	Sometimes (5–29%)
Pectus excavatum of inferior sternum	Sometimes (5–29%)
Slender long bone	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Sometimes (5–29%)
Constipation	Sometimes (5–29%)
Tube feeding	Sometimes (5–29%)
Vomiting	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Excessive hairiness	Sometimes (5–29%)
Excessive sweating	Sometimes (5–29%)
Frontal upsweep of hair	Sometimes (5–29%)
Stretch marks	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent infections	Often (30–79%)
Asthma	Sometimes (5–29%)
Recurrent respiratory infections	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Obesity	Sometimes (5–29%)
Short stature	Sometimes (5–29%)
Tall stature	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Bulge in wall of large artery that carries blood away from heart	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Primary amenorrhea	Sometimes (5–29%)
Undescended testes	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Collapsed lung	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FBXO11 and how often each is seen. Find out more at hpo.jax.org.

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