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Trait

Reduced factor XIII activity

Decreased activity of coagulation factor XIII (also known as fibrin stabilizing factor). Activated Factor XIII cross-links fibrin polymers solidifying the clot.

HPO HP:0008357

Summary

Body system
Abnormality of blood and blood-forming tissues

6 genes linked to Reduced factor XIII activity

Changes in these genes cause rare conditions in which Reduced factor XIII activity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
F13A1coagulation factor XIII A chainAlwaysIn 2 conditions
F13Bcoagulation factor XIII B chainAlwaysIn 2 conditions
SLC37A4solute carrier family 37 member 4AlwaysIn 1 condition
BRAFB-Raf proto-oncogene, serine/threonine kinaseNot recordedIn 1 condition
MAP2K1mitogen-activated protein kinase kinase 1Not recordedIn 1 condition
PTPN11protein tyrosine phosphatase non-receptor type 11Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormality of the common coagulation pathway

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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