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Gene

CALM2

calmodulin 2

Summary

Cytogenetic location
2p21
Coordinates
Chromosome 2: 47,160,084–47,176,511 (GRCh38)
Exons
6 exons across 16.4 kb
Protein
149 amino acids
Also known as
PHKD, PHKD2, CAMII
MANE Select transcript
ENST00000272298.12NM_001743.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Catecholaminergic Polymorphic Ventricular Tachycardia

    • Ventricular Tachycardia, Familial

      An instance of ventricular tachycardia that is caused by an inherited modification of the individual's genome.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong
    • Polymorphic Ventricular Tachycardia

      A ventricular tachycardia that is irregular in rate and rhythm.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

  • Long QT Syndrome

    • A disorder of cardiac repolarisation marked by a prolonged QT interval and a risk of dangerous ventricular arrhythmias such as torsades de pointes.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      • On the ACMG secondary findings list
      What knowing changes

      Beta-blockers, ICD placement, activity restriction, genetic counseling

How CALM2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where CALM2 sits. CALM2 and 9 genes near it on chromosome 2, from 46,668,298 to 47,668,297.Chromosome 22p21p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.346.8 Mb47 Mb47.2 Mb47.4 Mb47.6 MbCRIPT: 46,616,416–46,685,037, forward strandCRIPTSOCS5: 46,698,423–46,781,466, forward strandSOCS5MCFD2: 46,895,793–46,941,855, reverse strandMCFD2TTC7A: 46,915,869–47,076,137, forward strandTTC7ASTPG4: 47,045,538–47,155,308, reverse strandSTPG4: 47,065,941–47,176,511, reverse strandCALM2: 47,160,084–47,176,511, reverse strandCALM2EPCAM: 47,345,158–47,387,601, forward strandEPCAMMSH2: 47,403,067–47,663,146, forward strandMSH2KCNK12: 47,509,290–47,570,993, reverse strandKCNK12Diagram of CALM2: 6 exons on the reverse strand of chromosome 2Exon 6: 2 known disease-causing sitesExon 5: 14 known disease-causing sitesExon 4: 1 known disease-causing siteExon 6: 47,160,084–47,160,804, 721 basesExon 5: 47,161,723–47,161,858, 136 basesExon 4: 47,162,286–47,162,392, 107 basesExon 3: 47,162,519–47,162,662, 144 basesExon 2: 47,170,734–47,170,764, 31 basesExon 1: 47,176,441–47,176,511, 71 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 16.4 kb; 450 of those bases code for the protein.

How a genome test reads CALM2

17

positions in CALM2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16.4 kb of CALM2, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CALM2 gene: calmodulin 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/calm2

Vancouver

Dante Labs. CALM2 gene: calmodulin 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/calm2

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