Traits

Traits linked to ARHGAP19

Rho GTPase activating protein 19

The Human Phenotype Ontology links 46 traits to ARHGAP19, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormal gait	Always
Decreased motor nerve conduction velocity	Always
Demyelinating motor neuropathy	Always
Falls	Always
Fluid-filled cyst in spinal cord	Always
Impaired distal proprioception	Always
Impaired distal vibration sensation	Always
Impaired temperature sensation	Always
Impaired toe-walking ability	Always
Mixed demyelinating and axonal polyneuropathy	Always
Motor axonal neuropathy	Always
Motor polyneuropathy	Always
Nerve damage causing decreased feeling and movement	Always
Peripheral axonal neuropathy	Always
Peripheral nerve disease	Always
High stepping	Very often (80–99%)
Babinski sign	Often (30–79%)
Decreased touch sensation in extremities	Often (30–79%)
Impaired vibratory sensation	Often (30–79%)
Waddling gait	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Absent ankle reflexes	Always
Absent knee jerk reflex	Always
Calf muscle pseudohypertrophy	Always
Decreased arm strength	Always
Distal lower limb muscle weakness	Always
Distal upper limb muscle weakness	Always
Foot drop	Always
Hand muscle weakness	Always
Lower limb muscle weakness	Always
Weakness of the intrinsic hand muscles	Always
Areflexia of lower limbs	Often (30–79%)
Dropped arches	Often (30–79%)
High-arched foot	Often (30–79%)
Increased size of calf muscles	Often (30–79%)
Distal upper limb amyotrophy	Sometimes (5–29%)
Hammertoe	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Fatty replacement of skeletal muscle	Always
Frequent falls	Always
Muscle spasm	Always
Weakness of outermost muscles	Always
Distal lower limb amyotrophy	Very often (80–99%)
Scoliosis	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Increased CSF protein concentration	Always
Mildly elevated creatine kinase	Always

Abnormality of the cardiovascular system

Trait	How often it is seen
Mitral regurgitation	Always

Constitutional symptom

Trait	How often it is seen
Lack of energy and strength	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ARHGAP19 and how often each is seen. Find out more at hpo.jax.org.

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