Trait
Asymmetric pupil sizes
Clinical name: Anisocoria
Anisocoria, or unequal pupil size, may represent a benign physiologic variant or a manifestation of disease.
Summary
- Also called
- Asymmetry of the pupils, Unequal pupil size, Unequal pupil dilatation
- Body system
- Abnormality of the eye
Reference genomeGRCh38hg38
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Get my Genome Test17 genes linked to Asymmetric pupil sizes
Changes in these genes cause rare conditions in which Asymmetric pupil sizes is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| AMOTL1angiomotin like 1 | Always | In 1 condition |
| WSB2WD repeat and SOCS box containing 2 | Always | In 1 condition |
| COL25A1collagen type XXV alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| DDX6DEAD-box helicase 6 | Sometimes (5–29%) | In 1 condition |
| GMPPAGDP-mannose pyrophosphorylase A | Sometimes (5–29%) | In 1 condition |
| KCTD1potassium channel tetramerization domain containing 1 | Sometimes (5–29%) | In 1 condition |
| KIF21Akinesin family member 21A | Sometimes (5–29%) | In 1 condition |
| PHOX2Apaired like homeobox 2A | Sometimes (5–29%) | In 1 condition |
| PMP22peripheral myelin protein 22 | Sometimes (5–29%) | In 1 condition |
| SH3TC2SH3 domain and tetratricopeptide repeats 2 | Sometimes (5–29%) | In 1 condition |
| TMEM67transmembrane protein 67 | Sometimes (5–29%) | In 1 condition |
| TUBA1Atubulin alpha 1a | Sometimes (5–29%) | In 1 condition |
| TUBB2Btubulin beta 2B class IIb | Sometimes (5–29%) | In 1 condition |
| TUBB3tubulin beta 3 class III | Sometimes (5–29%) | In 1 condition |
| AAASaladin WD repeat nucleoporin | Not recorded | In 1 condition |
| LOXL1lysyl oxidase like 1 | Not recorded | In 1 condition |
| SIN3ASIN3 transcription regulator family member A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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