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Gene

GLMN

glomulin, FKBP associated protein

Summary

Cytogenetic location
1p22.1
Coordinates
Chromosome 1: 92,246,402–92,298,987 (GRCh38)
Exons
19 exons across 52.6 kb
Protein
594 amino acids
Inheritance
Autosomal dominant
Also known as
FAP48, FAP68, GLML, GVM, FKBPAP
Previous symbols
VMGLOM
MANE Select transcript
ENST00000370360.8NM_053274.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Hereditary Vascular Malformations

    • Glomuvenous MalformationAutosomal dominant

      A condition caused by changes in GLMN that causes multiple bluish, often tender, skin lumps made of abnormal veins.

      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How GLMN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where GLMN sits. GLMN and 9 genes near it on chromosome 1, from 91,772,695 to 92,772,694.Chromosome 11p22.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4491.8 Mb92 Mb92.2 Mb92.4 Mb92.6 MbTGFBR3: 91,680,343–91,906,335, reverse strandTGFBR3BRDT: 91,949,343–92,014,426, forward strandBRDTEPHX4: 92,029,427–92,063,728, forward strandEPHX4SETSIP: 92,074,533–92,075,411, reverse strandSETSIPBTBD8: 92,080,305–92,184,725, forward strandBTBD8C1orf146: 92,217,915–92,245,813, forward strandC1orf146GLMN: 92,246,402–92,298,987, reverse strandGLMNRPAP2: 92,299,010–92,438,687, forward strandRPAP2GFI1: 92,472,360–92,486,925, reverse strandGFI1EVI5: 92,508,696–92,792,424, reverse strandEVI5Diagram of GLMN: 19 exons on the reverse strand of chromosome 1Exon 18: 1 known disease-causing siteExon 17: 2 known disease-causing sitesExon 16: 1 known disease-causing siteExon 15: 4 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 10: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 8: 8 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 3 known disease-causing sitesExon 2: 2 known disease-causing sitesExon 19: 92,246,402–92,246,646, 245 basesExon 18: 92,247,062–92,247,144, 83 basesExon 17: 92,247,878–92,247,989, 112 basesExon 16: 92,262,863–92,262,926, 64 basesExon 15: 92,263,623–92,263,732, 110 basesExon 14: 92,264,554–92,264,638, 85 basesExon 13: 92,266,419–92,266,492, 74 basesExon 12: 92,266,700–92,266,741, 42 basesExon 11: 92,267,913–92,268,002, 90 basesExon 10: 92,268,105–92,268,135, 31 basesExon 9: 92,269,723–92,269,776, 54 basesExon 8: 92,271,465–92,271,652, 188 basesExon 7: 92,286,490–92,286,592, 103 basesExon 6: 92,288,914–92,289,151, 238 basesExon 5: 92,290,198–92,290,306, 109 basesExon 4: 92,291,418–92,291,537, 120 basesExon 3: 92,297,404–92,297,529, 126 basesExon 2: 92,297,961–92,298,029, 69 basesExon 1: 92,298,925–92,298,987, 63 bases191510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 52.6 kb; 1,785 of those bases code for the protein.

How a genome test reads GLMN

43

positions in GLMN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 52.6 kb of GLMN, introns included, not only the 2 kb of exons.

Traits linked to GLMN

The Human Phenotype Ontology lists these as features of the rare conditions GLMN can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GLMN gene: glomulin, FKBP associated protein. Retrieved 17 October 2026, from https://dantelabs.com/genes/glmn

Vancouver

Dante Labs. GLMN gene: glomulin, FKBP associated protein [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/glmn

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