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Gene

TMC8

transmembrane channel like 8

Summary

Cytogenetic location
17q25.3
Coordinates
Chromosome 17: 78,130,771–78,142,968 (GRCh38)
Exons
16 exons across 12.2 kb
Protein
726 amino acids
Also known as
EVIN2
Previous symbols
EVER2
MANE Select transcript
ENST00000318430.10NM_152468.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TMC8 yet. The test sequences your whole genome, so your data includes it all the same.

How TMC8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where TMC8 sits. TMC8 and 11 genes near it on chromosome 17, from 77,636,870 to 78,636,869.Chromosome 1717q25.3p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.377.8 Mb78 Mb78.2 Mb78.4 Mb78.6 MbTNRC6C: 77,958,613–78,108,822, forward strandTNRC6CTMC6: 78,107,397–78,132,579, reverse strandTMC6TMC8: 78,130,771–78,142,968, forward strandTMC8IL40: 78,146,356–78,166,297, forward strandIL40SYNGR2: 78,168,545–78,176,005, forward strandSYNGR2TK1: 78,172,779–78,187,233, reverse strandTK1AFMID: 78,186,660–78,207,703, forward strandAFMIDBIRC5: 78,214,186–78,225,636, forward strandBIRC5TMEM235: 78,231,287–78,240,987, forward strandTMEM235SOCS3: 78,356,778–78,360,930, reverse strandSOCS3PGS1: 78,378,637–78,425,114, forward strandPGS1DNAH17: 78,423,697–78,577,396, reverse strandDNAH17Diagram of TMC8: 16 exons on the forward strand of chromosome 17Exon 2: 3 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 9: 4 known disease-causing sitesExon 10: 1 known disease-causing siteExon 11: 3 known disease-causing sitesExon 12: 3 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 1: 78,130,771–78,130,851, 81 basesExon 2: 78,131,281–78,131,737, 457 basesExon 3: 78,131,882–78,132,030, 149 basesExon 4: 78,132,359–78,132,508, 150 basesExon 5: 78,132,788–78,132,870, 83 basesExon 6: 78,133,406–78,133,542, 137 basesExon 7: 78,133,853–78,134,000, 148 basesExon 8: 78,134,394–78,134,564, 171 basesExon 9: 78,134,870–78,135,009, 140 basesExon 10: 78,137,235–78,137,358, 124 basesExon 11: 78,137,717–78,137,814, 98 basesExon 12: 78,138,005–78,138,188, 184 basesExon 13: 78,138,349–78,138,479, 131 basesExon 14: 78,138,574–78,138,732, 159 basesExon 15: 78,139,162–78,139,240, 79 basesExon 16: 78,140,834–78,142,968, 2,135 bases12468101214165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 12.2 kb; 2,181 of those bases code for the protein.

How a genome test reads TMC8

39

positions in TMC8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 12.2 kb of TMC8, introns included, not only the 4.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TMC8 gene: transmembrane channel like 8. Retrieved 16 October 2026, from https://dantelabs.com/genes/tmc8

Vancouver

Dante Labs. TMC8 gene: transmembrane channel like 8 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tmc8

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