Trait
High levels of ketone bodies
Clinical name: Ketosis
Presence of elevated levels of ketone bodies in the body.
Summary
- Also called
- Hyperketosis
- Body system
- Laboratory abnormality
Read the genes linked to High levels of ketone bodies, and the rest of your genome, with one test.
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Get my Genome Test29 genes linked to High levels of ketone bodies
Changes in these genes cause rare conditions in which High levels of ketone bodies is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FDXRferredoxin reductase | Always | In 1 condition |
| KARS1lysyl-tRNA synthetase 1 | Always | In 1 condition |
| KDM6Blysine demethylase 6B | Always | In 1 condition |
| MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 | Always | In 1 condition |
| GHSRgrowth hormone secretagogue receptor | Very often (80–99%) | In 1 condition |
| GYS2glycogen synthase 2 | Often (30–79%) | In 2 conditions |
| LYRM4LYR motif containing 4 | Often (30–79%) | In 1 condition |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Often (30–79%) | In 2 conditions |
| PHKG2phosphorylase kinase catalytic subunit gamma 2 | Often (30–79%) | In 2 conditions |
| POLR3KRNA polymerase III subunit K | Often (30–79%) | In 1 condition |
| PYGLglycogen phosphorylase L | Often (30–79%) | In 1 condition |
| ACADMacyl-CoA dehydrogenase medium chain | Sometimes (5–29%) | In 1 condition |
| FBP1fructose-bisphosphatase 1 | Sometimes (5–29%) | In 2 conditions |
| LRPPRCleucine rich pentatricopeptide repeat containing | Sometimes (5–29%) | In 1 condition |
| MLYCDmalonyl-CoA decarboxylase | Sometimes (5–29%) | In 2 conditions |
| PPP1R15Bprotein phosphatase 1 regulatory subunit 15B | Sometimes (5–29%) | In 1 condition |
| SLC5A2solute carrier family 5 member 2 | Sometimes (5–29%) | In 1 condition |
| TRMT10AtRNA methyltransferase 10A | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Rarely (1–4%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Rarely (1–4%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Rarely (1–4%) | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Rarely (1–4%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Rarely (1–4%) | In 1 condition |
| ABHD5abhydrolase domain containing 5, lysophosphatidic acid acyltransferase | Not recorded | In 1 condition |
| BCKDHAbranched chain keto acid dehydrogenase E1 subunit alpha | Not recorded | In 1 condition |
| GCDHglutaryl-CoA dehydrogenase | Not recorded | In 1 condition |
| MMAAmetabolism of cobalamin associated A | Not recorded | In 1 condition |
| MMABmetabolism of cobalamin associated B | Not recorded | In 1 condition |
| SLC37A4solute carrier family 37 member 4 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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