Trait

Severe faltering weight

Clinical name: Severe failure to thrive

Also called: Severe weight faltering, Marked failure to thrive, Severe postnatal failure to thrive
Body system: Growth abnormality

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/severe-failure-to-thrive.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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16 genes linked to Severe faltering weight

Changes in these genes cause rare conditions in which Severe faltering weight is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
LMNAlamin A/C	Very often (80–99%)	In 1 condition
ZMPSTE24zinc metallopeptidase STE24	Very often (80–99%)	In 1 condition
ASXL1ASXL transcriptional regulator 1	Often (30–79%)	In 1 condition
CPAPcentrosome assembly and centriole elongation protein	Often (30–79%)	In 1 condition
FIG4FIG4 phosphoinositide 5-phosphatase	Often (30–79%)	In 2 conditions
PRPS1phosphoribosyl pyrophosphate synthetase 1	Often (30–79%)	In 1 condition
RTTNrotatin	Often (30–79%)	In 1 condition
VAC14VAC14 component of PIKFYVE complex	Often (30–79%)	In 1 condition
BSNDbarttin CLCNK type accessory subunit beta	Sometimes (5–29%)	In 1 condition
CLCNKAchloride voltage-gated channel Ka	Sometimes (5–29%)	In 1 condition
CLCNKBchloride voltage-gated channel Kb	Sometimes (5–29%)	In 1 condition
ERCC6ERCC excision repair 6, chromatin remodeling factor	Not recorded	In 1 condition
HYMAIhydatidiform mole associated and imprinted	Not recorded	In 1 condition
PEX7peroxisomal biogenesis factor 7	Not recorded	In 1 condition
PLAGL1PLAG1 like zinc finger 1	Not recorded	In 1 condition
ZFP57ZFP57 zinc finger protein	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Faltering weight

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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