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Gene

MTHFD2

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Summary

Cytogenetic location
2p13.1
Coordinates
Chromosome 2: 74,198,615–74,217,565 (GRCh38)
Exons
8 exons across 19 kb
Protein
350 amino acids
MANE Select transcript
ENST00000394053.7NM_006636.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MTHFD2 yet. The test sequences your whole genome, so your data includes it all the same.

How MTHFD2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 2, with a bracket where MTHFD2 sits. MTHFD2 and 33 genes near it on chromosome 2, from 73,708,090 to 74,708,089.Chromosome 22p13.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.373.8 Mb74 Mb74.2 Mb74.4 Mb74.6 MbTPRKB: 73,709,704–73,737,421, reverse strandTPRKBDUSP11: 73,761,782–73,780,173, reverse strandDUSP11C2orf78: 73,784,183–73,817,148, forward strandC2orf78STAMBP: 73,828,916–73,873,670, forward strandSTAMBPACTG2: 73,892,232–73,919,865, forward strandACTG2DGUOK: 73,926,794–73,958,961, forward strandDGUOKTET3: 73,984,910–74,108,177, forward strandTET3BOLA3: 74,133,333–74,147,977, reverse strandBOLA3MOB1A: 74,152,528–74,178,932, reverse strandMOB1AMTHFD2: 74,198,615–74,217,565, forward strandMTHFD2: 74,211,604–74,363,377, reverse strandSLC4A5: 74,216,242–74,343,416, reverse strandSLC4A5DCTN1: 74,361,154–74,392,087, reverse strandDCTN1: 74,393,836–74,421,662, reverse strandC2orf81: 74,414,176–74,421,655, reverse strandC2orf81WDR54: 74,421,477–74,425,770, forward strandWDR54RTKN: 74,424,131–74,442,422, reverse strandRTKNINO80B: 74,455,078–74,457,958, forward strandINO80B-WBP1: 74,455,088–74,460,884, forward strandWBP1: 74,458,263–74,461,077, forward strandMOGS: 74,461,057–74,465,415, reverse strandMRPL53: 74,471,957–74,472,699, reverse strandCCDC142: 74,471,957–74,483,408, reverse strandTTC31: 74,482,617–74,496,915, forward strandTTC31LBX2: 74,497,455–74,503,316, reverse strandLBX2PCGF1: 74,505,041–74,508,361, reverse strandPCGF1TLX2: 74,513,463–74,517,148, forward strandTLX2DQX1: 74,518,131–74,526,396, reverse strandAUP1: 74,526,636–74,529,966, reverse strandHTRA2: 74,529,274–74,533,966, forward strandLOXL3: 74,531,716–74,555,718, reverse strandDOK1: 74,548,875–74,557,554, forward strandDOK1M1AP: 74,557,883–74,648,350, reverse strandM1APSEMA4F: 74,654,226–74,707,584, forward strandSEMA4FDiagram of MTHFD2: 8 exons on the forward strand of chromosome 2Exon 1: 74,198,615–74,198,742, 128 basesExon 2: 74,205,705–74,205,889, 185 basesExon 3: 74,207,704–74,207,826, 123 basesExon 4: 74,208,569–74,208,721, 153 basesExon 5: 74,209,942–74,210,049, 108 basesExon 6: 74,211,199–74,211,291, 93 basesExon 7: 74,211,741–74,211,866, 126 basesExon 8: 74,214,079–74,217,565, 3,487 bases123456785′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 19 kb; 1,053 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). MTHFD2 gene: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase. Retrieved 17 October 2026, from https://dantelabs.com/genes/mthfd2

Vancouver

Dante Labs. MTHFD2 gene: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mthfd2

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