Traits

Traits linked to HOXA13

homeobox A13

The Human Phenotype Ontology links 83 traits to HOXA13, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Abnormal scaphoid morphology	Always
Absent big toe	Always
Absent distal interphalangeal creases	Always
Absent outermost little finger bone	Always
Attachment of thumb close to wrist	Always
Broad big toe	Always
Broad distal hallux	Always
Broad innermost bone of the big toe	Always
Bunion	Always
Capitate-hamate fusion	Always
Club feet	Always
Curvature of digit	Always
Curvature of little finger	Always
Curvature of ring finger	Always
Dropped arches	Always
Extra little finger	Always
Fused ankle bones	Always
Fused bones of the midfoot	Always
Fused wrist bones	Always
Hallux varus	Always
Short 5th finger	Always
Short big toe	Always
Short foot	Always
Short middle bone of the little finger	Always
Short outermost bone of ring finger	Always
Short outermost bone of the index finger	Always
Short outermost bone of the middle finger	Always
Short outermost bone of toe	Always
Short outermost finger bone	Always
Short second toe	Always
Short thumb	Always
Shortened 1st long bone of hand	Always
Small hand	Always
Small outermost bone of big toe	Always
Small thenar eminence	Always
Tibial deviation of the 3rd toe	Always
Tibial deviation of the 4th toe	Always
Tibial deviation of the 5th toe	Always
Tibial deviation of toes	Always
Fusion of wrist bones	Very often (80–99%)
Short 1st long bone of foot	Very often (80–99%)
Shortening of all middle phalanges of the fingers	Very often (80–99%)
Delayed ankle bone maturation	Not recorded
Delayed maturation of wrist bone	Not recorded
Ulnar deviation of the 2nd finger	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal ureter morphology	Always
Double uterus	Always
Duplicate uterine cervix	Always
Glanular hypospadias	Always
Heart shaped uterus	Always
Hydronephrosis	Always
Kidney stone	Always
Lack of bladder control due to nervous system injury	Always
Longitudinal vaginal septum	Always
Penoscrotal hypospadias	Always
Pyelonephritis	Always
Small uterus	Always
Ureteropelvic junction obstruction	Always
Vesicoureteral reflux	Always
Abnormality of the uterus	Very often (80–99%)
Frequent urinary tract infections	Very often (80–99%)
Hypospadias	Often (30–79%)
Urethra issue	Often (30–79%)
Chordee	Not recorded
Cleft of scrotum	Not recorded
Renal failure	Not recorded
Short penis	Not recorded

Abnormality of the integument

Trait	How often it is seen
Absent nails	Always
Short nail	Always
Small fifth toenail	Always
Small nail	Always
Abnormal fingerprints	Often (30–79%)
Spinal dimple	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Always
Gallstones	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Filum terminale lipoma	Always
Pseudoepiphyses	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Tethered cord	Always
Widened subarachnoid space	Always

Abnormality of the cardiovascular system

Trait	How often it is seen
Hole in heart wall separating two lower heart chambers	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Small ears	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Elevated creatinine	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to HOXA13 and how often each is seen. Find out more at hpo.jax.org.

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