Traits

Traits linked to DCDC2

doublecortin domain containing 2

The Human Phenotype Ontology links 52 traits to DCDC2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Always
Jaundice	Always
Liver failure	Always
Portal fibrosis	Always
Sclerosing cholangitis	Always
Slowed or blocked flow of bile from liver	Always
Bile duct proliferation	Often (30–79%)
Ductal bile plugs	Often (30–79%)
Hepatic bridging fibrosis	Often (30–79%)
Hepatic fibrosis	Often (30–79%)
Malformation of the hepatic ductal plate	Often (30–79%)
Reduced number of intrahepatic bile ducts	Often (30–79%)
Scar tissue replaces healthy tissue in the liver	Often (30–79%)
Accumulation of fluid in the abdomen	Sometimes (5–29%)
Enlarged vein in esophagus	Sometimes (5–29%)
Excessive buildup of connective tissue and scarring of liver at birth	Sometimes (5–29%)
Biliary cirrhosis	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal renal interstitial morphology	Often (30–79%)
Chronic kidney disease	Often (30–79%)
Hyperechogenic kidneys	Often (30–79%)
Nephronophthisis	Often (30–79%)
Reduced renal corticomedullary differentiation	Often (30–79%)
Renal corticomedullary cysts	Often (30–79%)
Renal interstitial fibrosis	Often (30–79%)
Small kidneys	Often (30–79%)
Stage 5 chronic kidney disease	Often (30–79%)
Thickening of the tubular basement membrane	Often (30–79%)
Tubular luminal dilatation	Often (30–79%)
Kidney degeneration	Sometimes (5–29%)
Vesicoureteral reflux	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Extreme thirst	Often (30–79%)
Abnormal cerebral white matter morphology	Sometimes (5–29%)
Aggressive behavior	Sometimes (5–29%)
Agitation	Sometimes (5–29%)
Attention deficit	Sometimes (5–29%)
Diffuse cerebral atrophy	Sometimes (5–29%)
Intellectual disability, mild	Sometimes (5–29%)
Suicidal ideation	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Elevated gamma-glutamyltransferase level	Always
Abnormal urinary electrolyte concentration	Often (30–79%)
Clay colored stools	Often (30–79%)
Elevated alkaline phosphatase	Often (30–79%)
High bili total	Often (30–79%)
High liver enzymes	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Always
Portal hypertension	Always
Enlarged liver and spleen	Often (30–79%)
High blood pressure	Often (30–79%)
Carotid artery dilatation	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Low number of red blood cells or hemoglobin	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Always

Abnormality of the integument

Trait	How often it is seen
Itching	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DCDC2 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test