Traits

Traits linked to CERS3

ceramide synthase 3

The Human Phenotype Ontology links 20 traits to CERS3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Congenital nonbullous ichthyosiform erythroderma	Always
Decreased ability to sweat	Always
Hyperkeratosis	Always
Orthokeratosis	Always
Thickening of upper layer of skin	Always
Ichthyosis	Very often (80–99%)
Itching	Very often (80–99%)
Abnormality of the nail	Often (30–79%)
Hair loss	Often (30–79%)
Hypergranulosis	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Everted eyelid	Always
Outward turned lips	Always

Abnormality of limbs

Trait	How often it is seen
Palmar hyperlinearity	Always
Thickening of palms and soles	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Corneal inflammation	Often (30–79%)
Damage to outer layer of the cornea of the eye	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)
Short stature	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Red scaly skin caused by inflammatory skin disease	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CERS3 and how often each is seen. Find out more at hpo.jax.org.

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