Traits

Traits linked to SEMA4A

semaphorin 4A

The Human Phenotype Ontology links 90 traits to SEMA4A, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	Kaip dažnai pasireiškia
Abnormal electroretinogram	Labai dažnai (80–99%)
Abnormal retinal pigmentation	Labai dažnai (80–99%)
Blindness	Labai dažnai (80–99%)
Difficulties with night vision	Labai dažnai (80–99%)
Extreme sensitivity of the eyes to light	Labai dažnai (80–99%)
Involuntary, rapid, rhythmic eye movements	Labai dažnai (80–99%)
Optic atrophy	Labai dažnai (80–99%)
Progressive night blindness	Labai dažnai (80–99%)
Retina degeneration	Labai dažnai (80–99%)
Spicular pigmentation of the retina	Labai dažnai (80–99%)
Visual impairment	Labai dažnai (80–99%)
Abnormal central response of multifocal electroretinogram	Dažnai (30–79%)
Abnormal color vision	Dažnai (30–79%)
Abnormal full-field electroretinogram	Dažnai (30–79%)
Blind spot located at fixation point	Dažnai (30–79%)
Bulging cornea	Dažnai (30–79%)
Color blindness	Dažnai (30–79%)
Cystoid macular edema	Dažnai (30–79%)
Eye muscle paralysis	Dažnai (30–79%)
Glaucoma	Dažnai (30–79%)
Loss of peripheral vision	Dažnai (30–79%)
Optic disc drusen	Dažnai (30–79%)
Optic disc pallor	Dažnai (30–79%)
Photoreceptor outer segment loss on macular OCT	Dažnai (30–79%)
Posterior subcapsular cataract	Dažnai (30–79%)
Progressive loss of vision	Dažnai (30–79%)
Retinal atrophy	Dažnai (30–79%)
Amaurosis fugax	Kartais (5–29%)
Decreased clarity of vision	Kartais (5–29%)
Metamorphopsia	Kartais (5–29%)
Partial loss of field of vision	Kartais (5–29%)
Photopsia	Kartais (5–29%)
Increased tears	Neužfiksuota
Macular degeneration	Neužfiksuota
Rod-cone dystrophy	Neužfiksuota

Abnormality of the nervous system

Trait	Kaip dažnai pasireiškia
Glioblastoma multiforme	Labai dažnai (80–99%)
Anxiety	Dažnai (30–79%)
Attention deficit	Dažnai (30–79%)
Behavioral abnormality	Dažnai (30–79%)
Depression	Dažnai (30–79%)
Epilepsy	Dažnai (30–79%)
Irritability	Dažnai (30–79%)
Migraine	Dažnai (30–79%)
Rise in pressure inside skull	Dažnai (30–79%)
Abnormal gait	Kartais (5–29%)
Abnormal pyramidal sign	Kartais (5–29%)
Abnormal speech pattern	Kartais (5–29%)
Benign neoplasm of the central nervous system	Kartais (5–29%)
Cancer of early nerve cells	Kartais (5–29%)
Difficulty articulating speech	Kartais (5–29%)
Disorder of involuntary muscle movements	Kartais (5–29%)
Disturbed sensory perception	Kartais (5–29%)
Dysgraphia	Kartais (5–29%)
Hallucinations	Kartais (5–29%)
Loss of developmental milestones	Kartais (5–29%)
Memory impairment	Kartais (5–29%)
Paralysis or weakness of one side of body	Kartais (5–29%)
Pins and needles feeling	Kartais (5–29%)

Abnormality of the digestive system

Trait	Kaip dažnai pasireiškia
Abdominal pain	Labai dažnai (80–99%)
Constipation	Labai dažnai (80–99%)
Malabsorption	Labai dažnai (80–99%)
Nausea and vomiting	Dažnai (30–79%)
Rectal tumor	Dažnai (30–79%)
Cancer of the pancreas	Kartais (5–29%)
Colon tumor	Kartais (5–29%)
Hepatocellular carcinoma	Kartais (5–29%)
Pancreatic adenocarcinoma	Kartais (5–29%)
Stomach cancer	Retai (1–4 %)

Abnormality of the genitourinary system

Trait	Kaip dažnai pasireiškia
Urinary tract neoplasm	Kartais (5–29%)
Uterine cancer	Retai (1–4 %)
Kidney cancer	Neužfiksuota
Ovarian cancer	Neužfiksuota

Abnormality of the musculoskeletal system

Trait	Kaip dažnai pasireiškia
Low muscle tone	Dažnai (30–79%)
Spasticity and rigidity of muscles	Dažnai (30–79%)
Flexed joint that cannot be straightened	Kartais (5–29%)
Skeletal tumor	Kartais (5–29%)

Abnormality of the cardiovascular system

Trait	Kaip dažnai pasireiškia
Abnormality of retina blood vessels	Labai dažnai (80–99%)
Narrowing of blood vessels in back of eye	Dažnai (30–79%)
Cardiac diverticulum	Kartais (5–29%)

Abnormality of the ear

Trait	Kaip dažnai pasireiškia
Conductive deafness	Labai dažnai (80–99%)
Sensorineural hearing impairment	Labai dažnai (80–99%)

Abnormality of the endocrine system

Trait	Kaip dažnai pasireiškia
Neoplasm of the thyroid gland	Kartais (5–29%)
Noncancerous tumor in pituitary gland	Kartais (5–29%)

Laboratory abnormality

Trait	Kaip dažnai pasireiškia
Hyperinsulinemia	Dažnai (30–79%)
Abnormality of creatine metabolism	Kartais (5–29%)

Abnormality of blood and blood-forming tissues

Trait	Kaip dažnai pasireiškia
Gastrointestinal bleeding	Dažnai (30–79%)

Abnormality of the breast

Trait	Kaip dažnai pasireiškia
Breast tumor	Neužfiksuota

Abnormality of the integument

Trait	Kaip dažnai pasireiškia
Basal cell carcinoma	Kartais (5–29%)

Constitutional symptom

Trait	Kaip dažnai pasireiškia
Fatigue	Labai dažnai (80–99%)

Growth abnormality

Trait	Kaip dažnai pasireiškia
Weight loss	Labai dažnai (80–99%)

Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.

Iš kur tai žinoma

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SEMA4A and how often each is seen. Find out more at hpo.jax.org.

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