Traits

Traits linked to WDR26

WD repeat domain 26

The Human Phenotype Ontology links 91 traits to WDR26, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Full lower lip	Always
Big maxilla	Very often (80–99%)
Coarse facial features	Very often (80–99%)
Drooping upper lip	Very often (80–99%)
Full cheeks	Very often (80–99%)
Full upper lip	Very often (80–99%)
Widely spaced teeth	Very often (80–99%)
Abnormality of the gums	Often (30–79%)
Absent cupid's bow	Often (30–79%)
Broad nasal tip	Often (30–79%)
Delayed loss of baby teeth	Often (30–79%)
Depressed nasal bridge	Often (30–79%)
Full lips	Often (30–79%)
Limited hair on end of eyebrow	Often (30–79%)
Little lower jaw	Often (30–79%)
Narrow forehead	Often (30–79%)
Nasal tip, upturned	Often (30–79%)
Prominent nasal tip	Often (30–79%)
Short nasal bridge	Often (30–79%)
Short philtrum	Often (30–79%)
Wide mouth	Often (30–79%)
Abnormally small head	Sometimes (5–29%)
Broad head shape	Sometimes (5–29%)
Cleft palate	Sometimes (5–29%)
Collapsed nostrils	Sometimes (5–29%)
Gum enlargement	Sometimes (5–29%)
Midface retrusion	Sometimes (5–29%)
Prominent brow	Sometimes (5–29%)
Thin red part of the upper lip	Sometimes (5–29%)
Upward slanting of the opening between the eyelids	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Intellectual disability	Always
Delayed speech and language development	Very often (80–99%)
Epilepsy	Very often (80–99%)
Happy demeanor	Very often (80–99%)
Brain imaging abnormality	Often (30–79%)
Brief seizures with staring spells	Often (30–79%)
Delayed ability to sit	Often (30–79%)
Delayed ability to walk	Often (30–79%)
Febrile seizure (within the age range of 3 months to 6 years)	Often (30–79%)
Grand mal seizures	Often (30–79%)
Mild global developmental delay	Often (30–79%)
Severe global developmental delay	Often (30–79%)
Abducens palsy	Sometimes (5–29%)
Absent speech development	Sometimes (5–29%)
Autism spectrum disorder	Sometimes (5–29%)
Cerebral hypomyelination	Sometimes (5–29%)
Fewer and broader ridges in brain	Sometimes (5–29%)
Inability to coordinate movements when walking	Sometimes (5–29%)
Repetitive compulsive behavior	Sometimes (5–29%)
Repetitive movements	Sometimes (5–29%)
Small cerebellum	Sometimes (5–29%)
Stereotypical body rocking	Sometimes (5–29%)
Thin corpus callosum	Sometimes (5–29%)
Underdevelopment of part of brain called corpus callosum	Sometimes (5–29%)
Ventriculomegaly	Sometimes (5–29%)
Wide based walk	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Often (30–79%)
Farsightedness	Often (30–79%)
Increased front to back length of eyeball	Often (30–79%)
Increased size of eyes	Often (30–79%)
Wide-set eyes	Often (30–79%)
Bulging eye	Sometimes (5–29%)
Close sighted	Sometimes (5–29%)
Lazy eye	Sometimes (5–29%)
Marcus Gunn jaw winking synkinesis	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of little finger	Often (30–79%)
Attachment of thumb close to wrist	Sometimes (5–29%)
Front half of foot turns inward	Sometimes (5–29%)
High-arched foot	Sometimes (5–29%)
Osteopathia striata	Sometimes (5–29%)
Short foot	Sometimes (5–29%)
Small hand	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Often (30–79%)
Constipation	Often (30–79%)
Feeding difficulties	Often (30–79%)
Feeding difficulties in infancy	Often (30–79%)
Gastrostomy tube feeding in infancy	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Often (30–79%)
Abnormal formation of the hip	Sometimes (5–29%)
Abnormally shaped skeletal	Sometimes (5–29%)
Lower-limb joint contracture	Sometimes (5–29%)
Spastic walk	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Hole in heart wall separating two lower heart chambers	Sometimes (5–29%)
Right aortic arch	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Often (30–79%)
Abnormal Eustachian tube morphology	Sometimes (5–29%)

Abnormality of the endocrine system

Trait	How often it is seen
Pineal cyst	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Excessive hairiness	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Floppy windpipe	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to WDR26 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test