Trait

Absent cupid's bow

Lack of paramedian peaks and median notch of the upper lip vermilion.

HPO HP:0010800

Also called: Lack of cupid's bow, Missing cupid's bow, Agenesis of cupid's bow, Failure of development of cupid's bow
Body system: Abnormality of head or neck

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4 genes linked to Absent cupid's bow

Changes in these genes cause rare conditions in which Absent cupid's bow is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
WDR26WD repeat domain 26	Often (30–79%)	In 2 conditions
CEP295centrosomal protein 295	Sometimes (5–29%)	In 1 condition
DDX59DEAD-box helicase 59	Sometimes (5–29%)	In 1 condition
WACWW domain containing adaptor with coiled-coil	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the red part of the upper lip

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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