Traits

Traits linked to TRIM63

tripartite motif containing 63

The Human Phenotype Ontology links 31 traits to TRIM63, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Atrial flutter	Always
Cardiac failure	Always
Disease of the heart muscle	Always
Left atrial enlargement	Always
Left ventricular hypertrophy	Always
Mildly reduced left ventricular ejection fraction	Always
Mini stroke	Always
Myocardial fibrosis	Always
Enlarged and thickened heart muscle	Very often (80–99%)
Asymmetric septal hypertrophy	Often (30–79%)
Concentric hypertrophic cardiomyopathy	Often (30–79%)
Angina pectoris	Sometimes (5–29%)
Fainting spell	Sometimes (5–29%)
Palpitations	Sometimes (5–29%)
Quivering upper heart chambers resulting in irregular heartbeat	Sometimes (5–29%)
Restrictive cardiomyopathy	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Centrally nucleated skeletal muscle fibers	Always
Difficulty walking up stairs	Always
EMG: myopathic abnormalities	Always
Fatty replacement of skeletal muscle	Always
Increased endomysial connective tissue	Always
Increased variability in muscle fiber diameter	Always
Muscle tissue disease	Always
Proximal neurogenic muscle weakness	Always
Reduced spine movement	Always

Abnormality of the nervous system

Trait	How often it is seen
Decreased muscle movement	Always
Decreased reflex response	Always
Waddling gait	Always

Abnormality of the respiratory system

Trait	How often it is seen
Reduced forced vital capacity	Always
Breathing difficulty	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Increased size of calf muscles	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TRIM63 and how often each is seen. Find out more at hpo.jax.org.

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