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Gene

PAICS

phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase

Summary

Cytogenetic location
4q12
Coordinates
Chromosome 4: 56,436,260–56,464,578 (GRCh38)
Exons
9 exons across 28.3 kb
Protein
425 amino acids
Also known as
ADE2H1, AIRC
Previous symbols
PAIS
MANE Select transcript
ENST00000512576.3NM_001079524.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PAICS yet. The test sequences your whole genome, so your data includes it all the same.

How PAICS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 4, with a bracket where PAICS sits. PAICS and 10 genes near it on chromosome 4, from 55,950,419 to 56,950,418.Chromosome 44q12p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.256 Mb56.2 Mb56.4 Mb56.6 Mb56.8 MbCEP135: 55,948,819–56,033,361, forward strandCEP135CRACD: 56,049,091–56,330,609, forward strandCRACDAASDH: 56,337,482–56,387,523, reverse strandAASDHPPAT: 56,393,362–56,436,038, reverse strandPPATPAICS: 56,436,260–56,464,578, forward strandPAICSSRP72: 56,467,591–56,503,891, forward strandSRP72ARL9: 56,505,209–56,524,959, forward strandARL9SPMAP2L: 56,530,601–56,603,556, forward strandSPMAP2LHOPX: 56,647,195–56,681,877, reverse strandHOPXSPINK2: 56,809,857–56,821,869, reverse strandSPINK2REST: 56,907,853–56,967,011, forward strandRESTDiagram of PAICS: 9 exons on the forward strand of chromosome 4Exon 1: 56,436,260–56,436,328, 69 basesExon 2: 56,441,663–56,441,860, 198 basesExon 3: 56,446,695–56,446,873, 179 basesExon 4: 56,448,418–56,448,597, 180 basesExon 5: 56,448,710–56,448,823, 114 basesExon 6: 56,450,619–56,450,702, 84 basesExon 7: 56,451,872–56,452,052, 181 basesExon 8: 56,453,603–56,453,761, 159 basesExon 9: 56,459,372–56,464,578, 5,207 bases1246895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.4 kb of the gene's 28.3 kb; 1,278 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). PAICS gene: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase. Retrieved 16 October 2026, from https://dantelabs.com/genes/paics

Vancouver

Dante Labs. PAICS gene: phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/paics

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