Traits

Traits linked to SDHC

succinate dehydrogenase complex subunit C

The Human Phenotype Ontology links 94 traits to SDHC, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Very often (80–99%)
Diarrhea	Very often (80–99%)
Gastrointestinal stroma tumor	Very often (80–99%)
Nausea and vomiting	Very often (80–99%)
Stomach tumor	Very often (80–99%)
Accumulation of fluid in the abdomen	Often (30–79%)
Constipation	Often (30–79%)
Intermittent abdominal pain	Often (30–79%)
Intestinal obstruction	Often (30–79%)
Nausea	Often (30–79%)
Poor swallowing	Often (30–79%)
Abdominal mass	Sometimes (5–29%)
Abnormality of the liver	Sometimes (5–29%)
Anorexia	Sometimes (5–29%)
Colon tumor	Sometimes (5–29%)
Esophageal tumor	Sometimes (5–29%)
Gastrointestinal tract tumor	Sometimes (5–29%)
Rectal tumor	Sometimes (5–29%)
Small intestine tumor	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Decrease in blood pressure upon standing up	Often (30–79%)
Elevated heart rate	Often (30–79%)
Fainting spell	Often (30–79%)
High blood pressure	Often (30–79%)
Hypertension associated with pheochromocytoma	Often (30–79%)
Hypertensive retinopathy	Often (30–79%)
Palpitations	Often (30–79%)
Positive regitine blocking test	Often (30–79%)
Sinus tachycardia	Often (30–79%)
Swollen lymph nodes in center of chest	Often (30–79%)
Abnormal heart rate	Sometimes (5–29%)
Arachnoid hemangiomatosis	Sometimes (5–29%)
Cardiac failure	Sometimes (5–29%)
Disease of the heart muscle	Sometimes (5–29%)
Hypertensive crisis	Sometimes (5–29%)
Inflammation of heart muscle	Sometimes (5–29%)
Swollen lymph nodes	Sometimes (5–29%)
Hives	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Paraganglioma	Always
Adrenal pheochromocytoma	Very often (80–99%)
Extraadrenal pheochromocytoma	Very often (80–99%)
Pheochromocytoma	Very often (80–99%)
Adrenal overactivity	Often (30–79%)
Adrenocortical adenoma	Often (30–79%)
Paraganglioma of head and neck	Often (30–79%)
Chemodectoma	Not recorded
Elevated circulating catecholamine level	Not recorded
Glomus jugular tumor	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Cranial nerve paralysis	Often (30–79%)
Episodic paroxysmal anxiety	Often (30–79%)
Recurrent paroxysmal headache	Often (30–79%)
Cranial nerve compression	Sometimes (5–29%)
Headache	Sometimes (5–29%)
Inability to move vocal cords	Sometimes (5–29%)
Panic attack	Sometimes (5–29%)
Tremor	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Elevated urinary dopamine	Often (30–79%)
Elevated urinary epinephrine level	Often (30–79%)
Elevated urinary norepinephrine level	Often (30–79%)
High blood calcium levels	Often (30–79%)
High urine protein levels	Often (30–79%)
Blood in urine	Sometimes (5–29%)
Elevated calcitonin	Sometimes (5–29%)
High blood sugar	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Flushing	Often (30–79%)
Sporadic excessive sweating	Often (30–79%)
Irregular hyperpigmentation	Sometimes (5–29%)
Paleness	Sometimes (5–29%)
Excessive sweating	Not recorded
Neurofibroma	Not recorded
Patchy darkened skin	Not recorded

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Often (30–79%)
Paroxysmal vertigo	Often (30–79%)
Pulsatile tinnitus	Often (30–79%)
Ringing in ears	Often (30–79%)
Conductive deafness	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Gastrointestinal bleeding	Very often (80–99%)
Bleeding in brain	Often (30–79%)
Low number of red blood cells or hemoglobin	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Glomerular sclerosis	Often (30–79%)
Cancer starting in small tubes in kidneys	Sometimes (5–29%)
Renal failure	Sometimes (5–29%)

Abnormality of the voice

Trait	How often it is seen
Inability to produce voice sounds	Often (30–79%)
Hoarse voice	Not recorded
Loss of voice	Not recorded

Abnormal tissue mass

Trait	How often it is seen
Cancer of connective tissue	Very often (80–99%)
Leiomyosarcoma	Very often (80–99%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)
Chest pain	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Retinal capillary hemangioma	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Large hands	Not recorded

Abnormality of the eye

Trait	How often it is seen
Absent iris	Rarely (1–4%)

Abnormality of the immune system

Trait	How often it is seen
Skin rash	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Lung infiltrates	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Weight loss	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SDHC and how often each is seen. Find out more at hpo.jax.org.

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