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Gene

MLKL

mixed lineage kinase domain like pseudokinase

Summary

Cytogenetic location
16q23.1
Coordinates
Chromosome 16: 74,671,855–74,700,862 (GRCh38)
Exons
11 exons across 29 kb
Protein
471 amino acids
Also known as
FLJ34389
MANE Select transcript
ENST00000308807.12NM_152649.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MLKL yet. The test sequences your whole genome, so your data includes it all the same.

How MLKL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 16, with a bracket where MLKL sits. MLKL and 10 genes near it on chromosome 16, from 74,186,359 to 75,186,358.Chromosome 1616q23.1p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.374.2 Mb74.4 Mb74.6 Mb74.8 Mb75 MbPSMD7: 74,296,781–74,306,290, forward strandPSMD7NPIPB15: 74,376,306–74,392,115, forward strandNPIPB15CLEC18B: 74,408,631–74,424,179, reverse strandCLEC18BGLG1: 74,447,427–74,607,144, reverse strandGLG1RFWD3: 74,621,393–74,666,912, reverse strandRFWD3MLKL: 74,671,855–74,700,862, reverse strandMLKLFA2H: 74,712,955–74,774,837, reverse strandFA2HWDR59: 74,862,165–75,000,173, reverse strandWDR59ZNRF1: 74,999,007–75,110,994, forward strandZNRF1LDHD: 75,111,855–75,116,799, reverse strandLDHDZFP1: 75,148,494–75,172,254, forward strandZFP1Diagram of MLKL: 11 exons on the reverse strand of chromosome 16Exon 11: 74,671,855–74,672,538, 684 basesExon 10: 74,674,960–74,675,100, 141 basesExon 9: 74,675,355–74,675,404, 50 basesExon 8: 74,675,613–74,675,764, 152 basesExon 7: 74,678,899–74,678,980, 82 basesExon 6: 74,682,651–74,682,786, 136 basesExon 5: 74,685,486–74,685,583, 98 basesExon 4: 74,691,277–74,691,463, 187 basesExon 3: 74,692,342–74,692,416, 75 basesExon 2: 74,695,298–74,695,759, 462 basesExon 1: 74,700,453–74,700,862, 410 bases1110864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 29 kb; 1,416 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). MLKL gene: mixed lineage kinase domain like pseudokinase. Retrieved 17 October 2026, from https://dantelabs.com/genes/mlkl

Vancouver

Dante Labs. MLKL gene: mixed lineage kinase domain like pseudokinase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mlkl

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