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Gene

BEAN1

brain expressed associated with NEDD4 1

Summary

Cytogenetic location
16q21
Coordinates
Chromosome 16: 66,427,295–66,482,833 (GRCh38)
Exons
5 exons across 55.5 kb
Protein
259 amino acids
Inheritance
Autosomal dominant
Previous symbols
SCA31
MANE Select transcript
ENST00000536005.7NM_001178020.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Autosomal Dominant Cerebellar Ataxias (SCAs and DRPLA)

    • Autosomal Dominant Cerebellar AtaxiaAutosomal dominant

      A group of dominantly inherited ataxias, including SCA1, SCA2, SCA3 (Machado-Joseph disease), SCA6, SCA7, SCA17, SCA27B and DRPLA, caused by repeat expansions or point variants in genes such as ATXN1, ATXN2, ATXN3, CACNA1A, ATXN7, TBP, ATN1 and FGF14.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Genetic counselling and presymptomatic testing for relatives, physiotherapy and symptom management; some forms, such as SCA27B, may respond to specific medication.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How BEAN1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 16, with a bracket where BEAN1 sits. BEAN1 and 18 genes near it on chromosome 16, from 65,955,064 to 66,955,063.Chromosome 1616q21p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.366 Mb66.2 Mb66.4 Mb66.6 Mb66.8 MbCDH5: 66,366,588–66,404,784, forward strandCDH5BEAN1: 66,427,295–66,482,833, forward strandBEAN1: 66,469,812–66,517,312, reverse strandTK2: 66,508,003–66,552,544, reverse strandTK2CKLF: 66,552,563–66,566,251, forward strandCKLFCKLF-CMTM1: 66,552,587–66,579,135, forward strandCKLF-CMTM1CMTM1: 66,566,393–66,579,137, forward strandCMTM1CMTM2: 66,579,432–66,588,280, forward strandCMTM2CMTM3: 66,603,874–66,613,892, forward strandCMTM3CMTM4: 66,614,750–66,696,856, reverse strandCMTM4DYNC1LI2: 66,720,893–66,751,856, reverse strandDYNC1LI2TERB1: 66,754,640–66,801,620, reverse strandTERB1NAE1: 66,802,874–66,873,256, reverse strandNAE1CA7: 66,844,414–66,854,153, forward strandCA7PDP2: 66,878,589–66,895,754, forward strandPDP2CDH16: 66,908,122–66,919,187, reverse strandCDH16RRAD: 66,921,682–66,926,308, reverse strandRRADCIAO2B: 66,931,938–66,934,929, reverse strandCIAO2BCES2: 66,934,433–66,945,096, forward strandCES2Diagram of BEAN1: 5 exons on the forward strand of chromosome 16Exon 1: 66,427,295–66,427,431, 137 basesExon 2: 66,437,595–66,437,701, 107 basesExon 3: 66,469,602–66,469,865, 264 basesExon 4: 66,477,560–66,477,710, 151 basesExon 5: 66,480,586–66,482,833, 2,248 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 55.5 kb; 780 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). BEAN1 gene: brain expressed associated with NEDD4 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/bean1

Vancouver

Dante Labs. BEAN1 gene: brain expressed associated with NEDD4 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/bean1

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