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Trait

Uncoordinated limb movement

Clinical name: Limb dysmetria

A type of dysmetria involving the limbs.

HPO HP:0002406

Summary

Body system
Abnormality of the nervous system

19 genes linked to Uncoordinated limb movement

Changes in these genes cause rare conditions in which Uncoordinated limb movement is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ITPR1inositol 1,4,5-trisphosphate receptor type 1AlwaysIn 2 conditions
DAB1DAB adaptor protein 1Often (30–79%)In 1 condition
GRM1glutamate metabotropic receptor 1Often (30–79%)In 1 condition
POLGDNA polymerase gamma, catalytic subunitOften (30–79%)In 1 condition
PPP2R2Bprotein phosphatase 2 regulatory subunit BbetaOften (30–79%)In 1 condition
WASHC5WASH complex subunit 5Often (30–79%)In 1 condition
CYP7B1cytochrome P450 family 7 subfamily B member 1Sometimes (5–29%)In 1 condition
RNASEH1ribonuclease H1Sometimes (5–29%)In 1 condition
RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2BSometimes (5–29%)In 1 condition
GBA2glucosylceramidase beta 2Not recordedIn 1 condition
JAM2junctional adhesion molecule 2Not recordedIn 1 condition
KCNC3potassium voltage-gated channel subfamily C member 3Not recordedIn 1 condition
MYORGmyogenesis regulating glycosidaseNot recordedIn 1 condition
NAA60N-alpha-acetyltransferase 60, NatF catalytic subunitNot recordedIn 1 condition
PDGFBplatelet derived growth factor subunit BNot recordedIn 1 condition
PDGFRBplatelet derived growth factor receptor betaNot recordedIn 1 condition
SLC20A2solute carrier family 20 member 2Not recordedIn 1 condition
XPR1xenotropic and polytropic retrovirus receptor 1Not recordedIn 1 condition
ZFHX3zinc finger homeobox 3Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Lack of coordination of movement

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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