Trait
Positive Romberg sign
The patient stands with the feet placed together and balance and is asked to close his or her eyes. A loss of balance upon eye closure is a positive Romberg sign and is interpreted as indicating a deficit in proprioception.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test31 genes linked to Positive Romberg sign
Changes in these genes cause rare conditions in which Positive Romberg sign is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ABCB7ATP binding cassette subfamily B member 7 | Always | In 1 condition |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| ITPR1inositol 1,4,5-trisphosphate receptor type 1 | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| PDXKpyridoxal kinase | Always | In 1 condition |
| RTN2reticulon 2 | Always | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Always | In 1 condition |
| TTPAalpha tocopherol transfer protein | Always | In 2 conditions |
| XRCC1X-ray repair cross complementing 1 | Always | In 1 condition |
| KNSTRNkinetochore localized astrin (SPAG5) binding protein | Often (30–79%) | In 1 condition |
| LITAFlipopolysaccharide induced TNF factor | Often (30–79%) | In 1 condition |
| NEFLneurofilament light chain | Often (30–79%) | In 1 condition |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Often (30–79%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 4 conditions |
| POLR3ARNA polymerase III subunit A | Often (30–79%) | In 1 condition |
| RNF170ring finger protein 170 | Often (30–79%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Often (30–79%) | In 3 conditions |
| FLVCR1FLVCR choline and heme transporter 1 | Sometimes (5–29%) | In 2 conditions |
| IRF2BPLinterferon regulatory factor 2 binding protein like | Sometimes (5–29%) | In 1 condition |
| MTTPmicrosomal triglyceride transfer protein | Sometimes (5–29%) | In 1 condition |
| OPA3outer mitochondrial membrane lipid metabolism regulator OPA3 | Sometimes (5–29%) | In 1 condition |
| RNASEH1ribonuclease H1 | Sometimes (5–29%) | In 1 condition |
| SH3TC2SH3 domain and tetratricopeptide repeats 2 | Sometimes (5–29%) | In 1 condition |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Sometimes (5–29%) | In 1 condition |
| TTRtransthyretin | Sometimes (5–29%) | In 1 condition |
| CAMTA1calmodulin binding transcription activator 1 | Not recorded | In 1 condition |
| MFN2mitofusin 2 | Not recorded | In 1 condition |
| PLD3phospholipase D family member 3 | Not recorded | In 1 condition |
| POU4F1POU class 4 homeobox 1 | Not recorded | In 1 condition |
| RFC1replication factor C subunit 1 | Not recorded | In 1 condition |
| TBPTATA-box binding protein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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