Traits

Traits linked to PLAG1

PLAG1 zinc finger

The Human Phenotype Ontology links 39 traits to PLAG1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Triangular face	Always
Little lower jaw	Very often (80–99%)
Prominent forehead	Very often (80–99%)
Relatively large head	Very often (80–99%)
Cleft palate	Often (30–79%)
Frontal bossing	Sometimes (5–29%)
Cancer of salivary gland	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal scrotum morphology	Often (30–79%)
Hypospadias	Often (30–79%)
Cleft of scrotum	Sometimes (5–29%)
Microphallus	Sometimes (5–29%)
Painful menstruation	Sometimes (5–29%)
Undescended testes	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Birth length less than 3rd percentile	Always
Growth delay as children	Very often (80–99%)
Prenatal growth deficiency	Very often (80–99%)
Small for gestational age	Very often (80–99%)
Decreased body weight	Often (30–79%)
Uneven or disproportionate growth of one body part compared to another	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of little finger	Very often (80–99%)
Short 5th finger	Often (30–79%)
Webbed fingers or toes	Often (30–79%)
Cleft hand	Sometimes (5–29%)
More than five fingers or toes on hands or feet	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Often (30–79%)
Motor delay	Often (30–79%)
Attention deficit	Sometimes (5–29%)
Global developmental delay	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Low levels of amniotic fluid	Often (30–79%)
Small placenta	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties in infancy	Always
Inguinal hernia	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Birthmark	Sometimes (5–29%)
Small fingernail	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormality of the cardiovascular system	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Underactive thyroid	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Asthma	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Low blood sugar	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PLAG1 and how often each is seen. Find out more at hpo.jax.org.

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