Traits

Traits linked to PARK7

Parkinsonism associated deglycase

The Human Phenotype Ontology links 41 traits to PARK7, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Anxiety	Always
Parkinsonism with favorable response to dopaminergic medication	Always
Slow movements	Always
Balance impairment	Often (30–79%)
Brisk reflexes	Often (30–79%)
Depression	Often (30–79%)
Disorder of involuntary muscle movements	Often (30–79%)
Hallucinations	Often (30–79%)
Lack of feeling, emotion, interest	Often (30–79%)
Leg dystonia	Often (30–79%)
Postural tremor	Often (30–79%)
Tremor	Often (30–79%)
Abnormal autonomic nervous system physiology	Sometimes (5–29%)
Abnormality of balance	Sometimes (5–29%)
Cognitive impairment	Sometimes (5–29%)
Dementia	Sometimes (5–29%)
Difficulty staying or falling asleep	Sometimes (5–29%)
Dystonia	Sometimes (5–29%)
Increased reflexes	Sometimes (5–29%)
Panic attack	Sometimes (5–29%)
Poor social interactions	Sometimes (5–29%)
Psychotic episodes	Sometimes (5–29%)
Resting tremor	Sometimes (5–29%)
Short attention span	Sometimes (5–29%)
Willis-Ekbom disease	Sometimes (5–29%)
Agitation	Rarely (1–4%)
Frontal lobe dementia	Rarely (1–4%)
Impulsivity	Rarely (1–4%)

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Sometimes (5–29%)
Delayed gastric emptying	Sometimes (5–29%)
Diarrhea	Sometimes (5–29%)
Nausea	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Rigidity	Always
Involuntary muscle stiffness, contraction, or spasm	Sometimes (5–29%)
Muscle spasm	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Eyelid spasm	Sometimes (5–29%)
Hyposmia	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Abnormal color vision	Sometimes (5–29%)
Double vision	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Female sexual dysfunction	Sometimes (5–29%)
Male sexual dysfunction	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to PARK7 and how often each is seen. Find out more at hpo.jax.org.

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