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Gene

TNS2

tensin 2

Summary

Cytogenetic location
12q13.13
Coordinates
Chromosome 12: 53,050,065–53,064,379 (GRCh38)
Exons
29 exons across 14.3 kb
Protein
1,409 amino acids
Also known as
KIAA1075, C1-TEN
Previous symbols
TENC1
MANE Select transcript
ENST00000314250.11NM_170754.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephrotic Syndrome

    • Nephrosis

      Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

      • 1 GenCC submitter rates it definitive or strong

How TNS2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 12, with a bracket where TNS2 sits. TNS2 and 37 genes near it on chromosome 12, from 52,557,222 to 53,557,221.Chromosome 1212q13.13p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3352.6 Mb52.8 Mb53 Mb53.2 Mb53.4 MbKRT74: 52,565,151–52,573,843, reverse strandKRT74KRT72: 52,585,589–52,601,538, reverse strandKRT72KRT73: 52,607,570–52,618,559, reverse strandKRT73KRT2: 52,644,558–52,652,211, reverse strandKRT2KRT1: 52,674,736–52,680,407, reverse strandKRT1KRT77: 52,689,626–52,703,524, reverse strandKRT77KRT76: 52,768,155–52,777,345, reverse strandKRT76KRT3: 52,789,685–52,796,117, reverse strandKRT3KRT4: 52,806,549–52,814,116, reverse strandKRT4KRT79: 52,821,408–52,834,312, reverse strandKRT79KRT78: 52,837,804–52,849,092, reverse strandKRT78KRT8: 52,897,182–52,949,954, reverse strandKRT8KRT18: 52,945,688–52,952,911, forward strandKRT18EIF4B: 53,006,263–53,042,230, forward strandEIF4BTNS2: 53,050,065–53,064,379, forward strandTNS2SPRYD3: 53,064,316–53,079,414, reverse strandSPRYD3IGFBP6: 53,097,436–53,102,345, forward strandIGFBP6SOAT2: 53,103,457–53,124,538, forward strandSOAT2CSAD: 53,157,663–53,180,933, reverse strandCSADZNF740: 53,180,555–53,195,142, forward strandZNF740ITGB7: 53,191,318–53,207,310, reverse strandITGB7RARG: 53,210,566–53,232,980, reverse strandRARG: 53,241,900–53,242,722, forward strandSLC61A1: 53,251,251–53,254,406, forward strandSLC61A1ESPL1: 53,268,248–53,293,643, forward strandESPL1PFDN5: 53,295,291–53,299,455, forward strandPFDN5MYG1: 53,299,695–53,307,181, forward strandMYG1AAAS: 53,307,456–53,324,864, reverse strandAAASSP7: 53,326,575–53,345,315, reverse strandSP7SP1: 53,380,135–53,416,446, forward strandSP1AMHR2: 53,423,672–53,431,672, forward strandAMHR2PRR13: 53,441,308–53,446,660, forward strandPRR13PCBP2: 53,451,900–53,484,618, forward strandPCBP2MAP3K12: 53,479,669–53,500,063, reverse strandMAP3K12TARBP2: 53,500,921–53,506,431, forward strandTARBP2NPFF: 53,506,684–53,507,491, reverse strandNPFFATF7-NPFF: 53,506,691–53,625,979, reverse strandATF7: 53,507,856–53,626,412, reverse strandDiagram of TNS2: 29 exons on the forward strand of chromosome 12Exon 1: 53,050,065–53,050,260, 196 basesExon 2: 53,051,855–53,051,963, 109 basesExon 3: 53,052,455–53,052,492, 38 basesExon 4: 53,053,411–53,053,449, 39 basesExon 5: 53,053,774–53,053,812, 39 basesExon 6: 53,053,965–53,054,014, 50 basesExon 7: 53,054,270–53,054,441, 172 basesExon 8: 53,055,186–53,055,236, 51 basesExon 9: 53,055,568–53,055,690, 123 basesExon 10: 53,055,781–53,055,845, 65 basesExon 11: 53,057,013–53,057,096, 84 basesExon 12: 53,057,567–53,057,679, 113 basesExon 13: 53,057,773–53,057,833, 61 basesExon 14: 53,058,027–53,058,102, 76 basesExon 15: 53,058,316–53,058,445, 130 basesExon 16: 53,058,572–53,058,637, 66 basesExon 17: 53,058,714–53,058,827, 114 basesExon 18: 53,059,047–53,060,258, 1,212 basesExon 19: 53,060,405–53,060,555, 151 basesExon 20: 53,060,675–53,061,264, 590 basesExon 21: 53,061,380–53,061,469, 90 basesExon 22: 53,061,815–53,061,940, 126 basesExon 23: 53,062,153–53,062,245, 93 basesExon 24: 53,062,376–53,062,453, 78 basesExon 25: 53,062,620–53,062,697, 78 basesExon 26: 53,063,089–53,063,257, 169 basesExon 27: 53,063,349–53,063,417, 69 basesExon 28: 53,063,563–53,063,592, 30 basesExon 29: 53,063,744–53,064,379, 636 bases1246810121416182022242628295′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 14.3 kb; 4,230 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TNS2 gene: tensin 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/tns2

Vancouver

Dante Labs. TNS2 gene: tensin 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tns2

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