Traits

Traits linked to GRIP1

glutamate receptor interacting protein 1

The Human Phenotype Ontology links 80 traits to GRIP1, by body system: features seen in people with one of the gene's rare conditions.

GRIP1

Abnormality of head or neck

Trait	How often it is seen
Beaked nose	Always
Little lower jaw	Always
Wide nose	Always
Absent tear duct	Very often (80–99%)
Cryptophthalmos	Very often (80–99%)
Malformed tear ducts	Very often (80–99%)
Abnormal of nasal shape	Often (30–79%)
Bad bite	Often (30–79%)
Cleft tongue	Often (30–79%)
Dental crowding	Often (30–79%)
Depressed nasal bridge	Often (30–79%)
Abnormally small head	Sometimes (5–29%)
Cleft nostril	Sometimes (5–29%)
Cleft of the mouth	Sometimes (5–29%)
Cleft upper lip	Sometimes (5–29%)
Cranial defect	Sometimes (5–29%)
Encephalocele	Sometimes (5–29%)
High palate	Sometimes (5–29%)
Midline nasal groove	Sometimes (5–29%)
Underdeveloped tissue around nostril	Sometimes (5–29%)
Wide nasal bridge	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Smaller than typical growth of scrotum	Always
Absent/small kidney	Very often (80–99%)
Urinary tract abnormalities	Very often (80–99%)
Abnormal vagina morphology	Often (30–79%)
Abnormally closed or absent vagina	Often (30–79%)
Ambiguous external genitalia	Often (30–79%)
Bilateral renal agenesis	Often (30–79%)
Female pseudohermaphroditism	Often (30–79%)
Underdeveloped bladder	Often (30–79%)
Underdeveloped penis	Often (30–79%)
Ureteral agenesis	Often (30–79%)
Heart shaped uterus	Sometimes (5–29%)
Hypospadias	Sometimes (5–29%)
Undescended testes	Sometimes (5–29%)
Urethral atresia	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Always
Abnormality of the middle ear	Often (30–79%)
Abnormality of the outer ear	Often (30–79%)
Abnormally shaped ears	Often (30–79%)
Ears rotated toward back of head	Often (30–79%)
Simple ear	Often (30–79%)
Absent ear canal	Sometimes (5–29%)
Conductive deafness	Sometimes (5–29%)
Small ears	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Absent anus	Often (30–79%)
Accumulation of fluid in the abdomen	Often (30–79%)
Anorectal anomaly	Often (30–79%)
Narrowing of anal opening	Often (30–79%)
Abnormal anus position	Sometimes (5–29%)
Omphalocele	Sometimes (5–29%)
Umbilical hernia	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Abnormal lung lobation	Often (30–79%)
Laryngeal hypoplasia	Often (30–79%)
Laryngeal stenosis	Often (30–79%)
Tracheal atresia	Often (30–79%)
Narrowing of windpipe	Sometimes (5–29%)
Poorly developed lungs	Sometimes (5–29%)
Subglottic stenosis	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Cutaneous syndactyly	Always
Short toe	Always
Finger syndactyly	Very often (80–99%)
Fused toes	Often (30–79%)
Limb undergrowth	Rarely (1–4%)

Abnormality of the eye

Trait	How often it is seen
Blindness	Very often (80–99%)
Abnormally small eyeball	Often (30–79%)
Absence of eyeballs	Often (30–79%)
Wide-set eyes	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Vertebral segmentation defect	Sometimes (5–29%)
Abnormality of the ribs	Rarely (1–4%)
Wide pubic symphysis	Rarely (1–4%)

Abnormality of the nervous system

Trait	How often it is seen
Too much cerebrospinal fluid in the brain	Often (30–79%)
Intellectual disability	Sometimes (5–29%)
Myelomeningocele	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Low levels of amniotic fluid	Often (30–79%)
Sonographic non-visualized fetal bladder	Often (30–79%)

Abnormality of the breast

Trait	How often it is seen
Wide-spaced nipples	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal cardiovascular system morphology	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Abnormal hair pattern	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Nonimmune hydrops fetalis	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GRIP1 and how often each is seen. Find out more at hpo.jax.org.

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