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Trait

Cleft nasal tip

Clinical name: Bifid nasal tip

A splitting of the nasal tip. Visually assessable vertical indentation, cleft, or depression of the nasal tip.

HPO HP:0000456

Summary

Also called
Cleft tip of nose, Notched nasal tip, Notched tip of nose, Bifid tip of nose
Body system
Abnormality of head or neck

20 genes linked to Cleft nasal tip

Changes in these genes cause rare conditions in which Cleft nasal tip is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ALX4ALX homeobox 4AlwaysIn 1 condition
ATP6V1B2ATPase H+ transporting V1 subunit B2AlwaysIn 1 condition
CPAPcentrosome assembly and centriole elongation proteinAlwaysIn 1 condition
H4C3H4 clustered histone 3AlwaysIn 1 condition
HSPA9heat shock protein family A (Hsp70) member 9AlwaysIn 1 condition
BCORBCL6 corepressorVery often (80–99%)In 2 conditions
FREM1FRAS1 related extracellular matrix 1Very often (80–99%)In 2 conditions
ZSWIM6zinc finger SWIM-type containing 6Very often (80–99%)In 2 conditions
CDH11cadherin 11Often (30–79%)In 1 condition
HNRNPKheterogeneous nuclear ribonucleoprotein KOften (30–79%)In 1 condition
NEK1NIMA related kinase 1Often (30–79%)In 1 condition
EFNB1ephrin B1Sometimes (5–29%)In 1 condition
FRMPD4FERM and PDZ domain containing 4Sometimes (5–29%)In 1 condition
KAT6Alysine acetyltransferase 6ASometimes (5–29%)In 1 condition
NAA10N-alpha-acetyltransferase 10, NatA catalytic subunitSometimes (5–29%)In 1 condition
RNU4-2RNA, U4 small nuclear 2Sometimes (5–29%)In 1 condition
SCNM1sodium channel modifier 1Sometimes (5–29%)In 1 condition
ALX3ALX homeobox 3Not recordedIn 1 condition
FZD2frizzled class receptor 2Not recordedIn 1 condition
TBC1D32TBC1 domain family member 32Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the nasal tip

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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