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Condition report · Dermatological

Ichthyosis Vulgaris

The most common inherited form of dry, scaly skin, caused by reduced filaggrin, a protein that helps form the skin barrier. Filaggrin variants are also linked to a higher chance of eczema.

A condition report looks for rare variants known to cause the conditions it covers.

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The condition we analyse

Ichthyosis vulgaris (filaggrin deficiency)

Dry, fine scaling, especially on the shins, with increased palm creases; one FLG variant gives a milder effect and two give a stronger one.

What a diagnosis changes

Regular emollients and skin-barrier care help, and carriers may benefit from extra attention to eczema and skin irritants.

Genes analysed

Also known as

common ichthyosis; fish scale disease

Includes 3 related subtypes ↓
  • autosomal dominant ichthyosis vulgaris
  • mild ichthyosis vulgaris
  • severe ichthyosis vulgaris
MONDO:0024304MedGen 38217

Limitations

  • The FLG gene contains a series of nearly identical repeated segments, which makes it harder to read accurately with standard sequencing, so some variants may be missed.

Other dermatological conditions

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