Skip to content
Use your HSA or FSA funds

Gene

KIF5B

kinesin family member 5B

Summary

Cytogenetic location
10p11.22
Coordinates
Chromosome 10: 32,009,015–32,056,425 (GRCh38)
Exons
26 exons across 47.4 kb
Protein
963 amino acids
Also known as
KNS, uKHC
Previous symbols
KNS1
MANE Select transcript
ENST00000302418.5NM_004521.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Osteogenesis Imperfecta

    • A group of inherited connective tissue disorders causing fragile bones that break easily, often with blue sclerae, hearing loss and dental problems.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Cyclic IV bisphosphonates (pamidronate, zoledronate); orthopedic rodding of long bones; physical therapy; denosumab (in clinical use for pediatric OI); romosozumab (in development); hearing monitoring; dental management for dentinogenesis imperfecta

How KIF5B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 10, with a bracket where KIF5B sits. KIF5B and 3 genes near it on chromosome 10, from 31,532,720 to 32,532,719.Chromosome 1010p11.22p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.331.6 Mb31.8 Mb32 Mb32.2 Mb32.4 MbARHGAP12: 31,805,398–31,928,876, reverse strandARHGAP12KIF5B: 32,009,015–32,056,425, reverse strandKIF5BEPC1: 32,267,660–32,378,807, reverse strandEPC1CCDC7: 32,446,103–32,882,874, forward strandCCDC7Diagram of KIF5B: 26 exons on the reverse strand of chromosome 10Exon 26: 32,009,015–32,011,516, 2,502 basesExon 25: 32,015,509–32,015,659, 151 basesExon 24: 32,017,143–32,017,359, 217 basesExon 23: 32,018,052–32,018,156, 105 basesExon 22: 32,018,316–32,018,387, 72 basesExon 21: 32,018,502–32,018,562, 61 basesExon 20: 32,019,858–32,019,959, 102 basesExon 19: 32,021,022–32,021,131, 110 basesExon 18: 32,021,226–32,021,287, 62 basesExon 17: 32,022,140–32,022,257, 118 basesExon 16: 32,022,848–32,023,036, 189 basesExon 15: 32,028,428–32,028,571, 144 basesExon 14: 32,031,073–32,031,279, 207 basesExon 13: 32,032,706–32,032,774, 69 basesExon 12: 32,033,845–32,034,038, 194 basesExon 11: 32,034,690–32,034,838, 149 basesExon 10: 32,035,522–32,035,667, 146 basesExon 9: 32,035,890–32,035,994, 105 basesExon 8: 32,037,254–32,037,378, 125 basesExon 7: 32,037,520–32,037,607, 88 basesExon 6: 32,038,163–32,038,218, 56 basesExon 5: 32,038,778–32,038,826, 49 basesExon 4: 32,039,327–32,039,431, 105 basesExon 3: 32,040,384–32,040,457, 74 basesExon 2: 32,048,464–32,048,551, 88 basesExon 1: 32,055,848–32,056,425, 578 bases262422201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.9 kb of the gene's 47.4 kb; 2,892 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KIF5B gene: kinesin family member 5B. Retrieved 16 October 2026, from https://dantelabs.com/genes/kif5b

Vancouver

Dante Labs. KIF5B gene: kinesin family member 5B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/kif5b

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test