Traits

Traits linked to CCT5

chaperonin containing TCP1 subunit 5

The Human Phenotype Ontology links 27 traits to CCT5, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Babinski sign	Always
Clonus	Always
Decreased amplitude of sensory action potentials	Always
Degeneration of the spinal cord	Always
Distal sensory impairment of all modalities	Always
Increased reflexes	Always
Abnormal autonomic nervous system physiology	Very often (80–99%)
Abnormal gait	Very often (80–99%)
Impaired pain sensation	Very often (80–99%)
Peripheral neuropathy	Very often (80–99%)
Abnormality of the spinal cord	Often (30–79%)
Decreased motor nerve conduction velocity	Often (30–79%)
Sensory axonal neuropathy	Often (30–79%)
Decreased sensation in extremities	Not recorded
Peripheral axonal neuropathy	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Distal muscle wasting	Always
Spastic walk	Always
Involuntary muscle stiffness, contraction, or spasm	Very often (80–99%)
Spastic paraplegia	Very often (80–99%)
Progressive spastic paraplegia	Often (30–79%)
Lower limb spasticity	Not recorded

Abnormality of limbs

Trait	How often it is seen
Foot bone infection	Sometimes (5–29%)
Abnormal feet structure	Not recorded

Abnormality of the integument

Trait	How often it is seen
Open skin sore	Very often (80–99%)
Acral ulceration	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Decreased circulating apolipoprotein B concentration	Always
Low blood triglyceride levels	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CCT5 and how often each is seen. Find out more at hpo.jax.org.

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