Traits

Traits linked to BICRA

BRD4 interacting chromatin remodeling complex associated protein

The Human Phenotype Ontology links 87 traits to BICRA, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Bulbous nose	Often (30–79%)
Downward slanting of the opening between the eyelids	Often (30–79%)
Eye folds	Often (30–79%)
Frontal bossing	Often (30–79%)
High frontal hairline	Often (30–79%)
High palate	Often (30–79%)
Long eyelashes	Often (30–79%)
Monobrow	Often (30–79%)
Narrow forehead	Often (30–79%)
Prominent nasal bridge	Often (30–79%)
Prominent nasal tip	Often (30–79%)
Abnormally small head	Sometimes (5–29%)
Bell's palsy	Sometimes (5–29%)
Big calvaria	Sometimes (5–29%)
Delayed cranial suture closure	Sometimes (5–29%)
Depressed nasal bridge	Sometimes (5–29%)
Full cheeks	Sometimes (5–29%)
Highly arched eyebrow	Sometimes (5–29%)
Little lower jaw	Sometimes (5–29%)
Long, narrow head	Sometimes (5–29%)
Low frontal hairline	Sometimes (5–29%)
Low hanging columella	Sometimes (5–29%)
Midface retrusion	Sometimes (5–29%)
Narrow eyelid opening	Sometimes (5–29%)
Nasal tip, upturned	Sometimes (5–29%)
Pointed chin	Sometimes (5–29%)
Prominent area between the eyebrows	Sometimes (5–29%)
Ridged cranial sutures	Sometimes (5–29%)
Sparse scalp hair	Sometimes (5–29%)
Submucous cleft hard palate	Sometimes (5–29%)
Thick eyebrow	Sometimes (5–29%)
Underdeveloped tissue around nostril	Sometimes (5–29%)
Upward slanting of the opening between the eyelids	Sometimes (5–29%)
Velopharyngeal incompetence	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Intellectual disability	Always
Autism spectrum disorder	Often (30–79%)
Behavioral abnormality	Often (30–79%)
Chiari malformation	Sometimes (5–29%)
Difficulty sleeping	Sometimes (5–29%)
Enlarged cerebellum	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Hippocampal atrophy	Sometimes (5–29%)
Loss of developmental milestones	Sometimes (5–29%)
Noncommunicating hydrocephalus	Sometimes (5–29%)
Repetitive movements	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Often (30–79%)
Ears rotated toward back of head	Sometimes (5–29%)
Large earlobe	Sometimes (5–29%)
Overfolding of the superior helices	Sometimes (5–29%)
Prominent antihelix	Sometimes (5–29%)
Prominent ear	Sometimes (5–29%)
Sensorineural hearing impairment	Sometimes (5–29%)
Simple ear	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Broad thumb	Sometimes (5–29%)
Cutaneous syndactyly	Sometimes (5–29%)
Fused forearm bones	Sometimes (5–29%)
Partial hip dislocation	Sometimes (5–29%)
Short thumb	Sometimes (5–29%)
Slender finger	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Often (30–79%)
Abnormally close eyes	Sometimes (5–29%)
Close sighted	Sometimes (5–29%)
Deeply set eye	Sometimes (5–29%)
Farsightedness	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Often (30–79%)
Double-Jointed	Sometimes (5–29%)
Funnel chest	Sometimes (5–29%)
Oral motor hypotonia	Sometimes (5–29%)
Scoliosis	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Chronic constipation	Often (30–79%)
Feeding difficulties	Often (30–79%)
Acid reflux	Sometimes (5–29%)
Celiac disease	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Heart murmur	Sometimes (5–29%)
Patent foramen ovale	Sometimes (5–29%)
Tetralogy of Fallot	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Horseshoe kidney	Sometimes (5–29%)
Hypospadias	Sometimes (5–29%)
Undescended testes	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)
Short stature	Sometimes (5–29%)

Abnormality of the breast

Trait	How often it is seen
Inverted nipples	Sometimes (5–29%)

Abnormality of the endocrine system

Trait	How often it is seen
Underactive thyroid	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Small nail	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
High liver enzymes	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to BICRA and how often each is seen. Find out more at hpo.jax.org.

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