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Gene

DNAH12

dynein axonemal heavy chain 12

Summary

Cytogenetic location
3p14.3
Coordinates
Chromosome 3: 57,293,700–57,544,344 (GRCh38)
Exons
74 exons across 250.6 kb
Protein
3,960 amino acids
Also known as
DLP12, Dnahc3, HL-19, hdhc3, DHC3, FLJ40427, FLJ44290
Previous symbols
DNHD2, DNAH12L, DNAH7L
MANE Select transcript
ENST00000495027.6NM_001366028.2
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Male Infertility

    • The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong

How DNAH12 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where DNAH12 sits. DNAH12 and 10 genes near it on chromosome 3, from 56,919,022 to 57,919,021.Chromosome 33p14.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2957 Mb57.2 Mb57.4 Mb57.6 Mb57.8 MbARHGEF3: 56,727,414–57,079,329, reverse strandARHGEF3SPATA12: 57,060,659–57,075,530, forward strandSPATA12IL17RD: 57,089,982–57,170,306, reverse strandIL17RDHESX1: 57,182,073–57,227,621, reverse strandHESX1APPL1: 57,227,708–57,289,540, forward strandAPPL1ASB14: 57,268,342–57,292,693, reverse strandASB14DNAH12: 57,293,700–57,544,344, reverse strandDNAH12PDE12: 57,556,249–57,656,494, forward strandPDE12ARF4: 57,571,363–57,598,220, reverse strandARF4DENND6A: 57,625,454–57,693,127, reverse strandDENND6ASLMAP: 57,755,450–57,931,461, forward strandSLMAPDiagram of DNAH12: 74 exons on the reverse strand of chromosome 3Exon 41: 1 known disease-causing siteExon 74: 57,293,700–57,293,971, 272 basesExon 73: 57,295,525–57,295,592, 68 basesExon 72: 57,296,344–57,296,435, 92 basesExon 71: 57,296,847–57,296,984, 138 basesExon 70: 57,301,735–57,301,939, 205 basesExon 69: 57,309,151–57,309,254, 104 basesExon 68: 57,309,666–57,309,854, 189 basesExon 67: 57,310,717–57,310,950, 234 basesExon 66: 57,314,494–57,314,631, 138 basesExon 65: 57,322,343–57,322,483, 141 basesExon 64: 57,323,007–57,323,260, 254 basesExon 63: 57,323,469–57,323,619, 151 basesExon 62: 57,334,465–57,334,609, 145 basesExon 61: 57,334,782–57,334,940, 159 basesExon 60: 57,352,085–57,352,225, 141 basesExon 59: 57,357,176–57,357,348, 173 basesExon 58: 57,363,594–57,363,786, 193 basesExon 57: 57,366,729–57,366,921, 193 basesExon 56: 57,368,046–57,368,260, 215 basesExon 55: 57,375,371–57,375,516, 146 basesExon 54: 57,375,818–57,375,965, 148 basesExon 53: 57,376,981–57,377,222, 242 basesExon 52: 57,379,158–57,379,298, 141 basesExon 51: 57,380,278–57,380,367, 90 basesExon 50: 57,382,262–57,382,393, 132 basesExon 49: 57,384,829–57,385,005, 177 basesExon 48: 57,385,349–57,385,429, 81 basesExon 47: 57,386,441–57,386,603, 163 basesExon 46: 57,387,086–57,387,219, 134 basesExon 45: 57,391,872–57,392,066, 195 basesExon 44: 57,394,171–57,394,332, 162 basesExon 43: 57,403,309–57,403,501, 193 basesExon 42: 57,404,969–57,405,147, 179 basesExon 41: 57,405,653–57,405,952, 300 basesExon 40: 57,408,280–57,408,535, 256 basesExon 39: 57,413,746–57,413,912, 167 basesExon 38: 57,415,426–57,415,564, 139 basesExon 37: 57,419,367–57,419,518, 152 basesExon 36: 57,421,518–57,421,706, 189 basesExon 35: 57,425,022–57,425,141, 120 basesExon 34: 57,428,633–57,428,821, 189 basesExon 33: 57,429,691–57,429,774, 84 basesExon 32: 57,433,367–57,433,507, 141 basesExon 31: 57,433,645–57,433,828, 184 basesExon 30: 57,436,951–57,437,060, 110 basesExon 29: 57,444,697–57,444,816, 120 basesExon 28: 57,445,174–57,445,419, 246 basesExon 27: 57,446,031–57,446,270, 240 basesExon 26: 57,446,537–57,446,689, 153 basesExon 25: 57,452,843–57,453,015, 173 basesExon 24: 57,453,247–57,453,403, 157 basesExon 23: 57,454,775–57,454,894, 120 basesExon 22: 57,457,721–57,458,003, 283 basesExon 21: 57,458,099–57,458,220, 122 basesExon 20: 57,459,592–57,459,786, 195 basesExon 19: 57,461,489–57,461,689, 201 basesExon 18: 57,462,690–57,462,875, 186 basesExon 17: 57,468,736–57,468,979, 244 basesExon 16: 57,470,443–57,470,636, 194 basesExon 15: 57,471,472–57,471,606, 135 basesExon 14: 57,472,546–57,472,671, 126 basesExon 13: 57,483,376–57,483,511, 136 basesExon 12: 57,489,509–57,489,687, 179 basesExon 11: 57,501,321–57,501,412, 92 basesExon 10: 57,502,323–57,502,479, 157 basesExon 9: 57,504,016–57,504,204, 189 basesExon 8: 57,507,643–57,507,838, 196 basesExon 7: 57,508,382–57,508,540, 159 basesExon 6: 57,509,140–57,509,212, 73 basesExon 5: 57,510,790–57,510,979, 190 basesExon 4: 57,523,583–57,523,609, 27 basesExon 3: 57,523,803–57,523,884, 82 basesExon 2: 57,542,701–57,542,903, 203 basesExon 1: 57,544,197–57,544,344, 148 bases7470656055504540353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 12.1 kb of the gene's 250.6 kb; 11,883 of those bases code for the protein.

How a genome test reads DNAH12

1

position in DNAH12 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 250.6 kb of DNAH12, introns included, not only the 12.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNAH12 gene: dynein axonemal heavy chain 12. Retrieved 17 October 2026, from https://dantelabs.com/genes/dnah12

Vancouver

Dante Labs. DNAH12 gene: dynein axonemal heavy chain 12 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dnah12

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