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Gene

PDXK

pyridoxal kinase

Summary

Cytogenetic location
21q22.3
Coordinates
Chromosome 21: 43,719,129–43,762,299 (GRCh38)
Exons
11 exons across 43.2 kb
Protein
312 amino acids
Also known as
PNK, PKH, FLJ21324, PRED79, FLJ31940, MGC15873
Previous symbols
C21orf97, C21orf124
MANE Select transcript
ENST00000291565.9NM_003681.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PDXK yet. The test sequences your whole genome, so your data includes it all the same.

How PDXK is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 21, with a bracket where PDXK sits. PDXK and 12 genes near it on chromosome 21, from 43,240,714 to 44,240,713.Chromosome 2121q22.3p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.343.4 Mb43.6 Mb43.8 Mb44 Mb44.2 MbSIK1: 43,414,483–43,427,137, reverse strandSIK1HSF2BP: 43,529,186–43,659,524, reverse strandHSF2BPH2BC12L: 43,565,182–43,565,648, forward strandH2BC12LRRP1B: 43,659,542–43,696,080, forward strandRRP1BPDXK: 43,719,129–43,762,299, forward strandPDXKCSTB: 43,772,511–43,776,608, reverse strandCSTBRRP1: 43,789,513–43,821,500, forward strandRRP1AGPAT3: 43,865,081–43,987,592, forward strandAGPAT3: 43,939,919–43,959,673, forward strandTRAPPC10: 44,012,280–44,106,553, forward strandTRAPPC10PWP2: 44,107,306–44,131,181, forward strandPWP2GATD3: 44,133,610–44,210,114, forward strandGATD3ICOSLG: 44,215,382–44,241,446, reverse strandICOSLGDiagram of PDXK: 11 exons on the forward strand of chromosome 21Exon 3: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 43,719,129–43,719,381, 253 basesExon 2: 43,734,069–43,734,123, 55 basesExon 3: 43,741,667–43,741,771, 105 basesExon 4: 43,743,724–43,743,807, 84 basesExon 5: 43,746,079–43,746,125, 47 basesExon 6: 43,748,995–43,749,080, 86 basesExon 7: 43,750,500–43,750,545, 46 basesExon 8: 43,752,518–43,752,629, 112 basesExon 9: 43,753,583–43,753,719, 137 basesExon 10: 43,755,698–43,755,764, 67 basesExon 11: 43,755,951–43,762,299, 6,349 bases12345678910115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.3 kb of the gene's 43.2 kb; 939 of those bases code for the protein.

How a genome test reads PDXK

2

positions in PDXK where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 43.2 kb of PDXK, introns included, not only the 7.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PDXK gene: pyridoxal kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/pdxk

Vancouver

Dante Labs. PDXK gene: pyridoxal kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pdxk

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