Trait
Numbness
Clinical name: Hypoesthesia
Decreased ability to perceive touch.
Summary
- Also called
- Hypoaesthesia
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
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Get my Genome Test29 genes linked to Numbness
Changes in these genes cause rare conditions in which Numbness is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Always | In 1 condition |
| FGD4FYVE, RhoGEF and PH domain containing 4 | Always | In 1 condition |
| LAMB1laminin subunit beta 1 | Always | In 1 condition |
| LITAFlipopolysaccharide induced TNF factor | Always | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Always | In 1 condition |
| NFU1NFU1 iron-sulfur cluster scaffold | Always | In 1 condition |
| PMP22peripheral myelin protein 22 | Always | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Always | In 2 conditions |
| SERPING1serpin family G member 1 | Always | In 1 condition |
| SPTAN1spectrin alpha, non-erythrocytic 1 | Always | In 1 condition |
| TYMPthymidine phosphorylase | Always | In 1 condition |
| ATL3atlastin GTPase 3 | Very often (80–99%) | In 1 condition |
| ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif 15 | Often (30–79%) | In 1 condition |
| ATP7BATPase copper transporting beta | Often (30–79%) | In 1 condition |
| BAG3BAG cochaperone 3 | Often (30–79%) | In 1 condition |
| CCM2CCM2 scaffold protein | Often (30–79%) | In 1 condition |
| KIF1Akinesin family member 1A | Often (30–79%) | In 1 condition |
| KRIT1KRIT1 ankyrin repeat containing | Often (30–79%) | In 1 condition |
| MEFVMEFV innate immunity regulator, pyrin | Often (30–79%) | In 1 condition |
| PDCD10programmed cell death 10 | Often (30–79%) | In 1 condition |
| PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | Often (30–79%) | In 1 condition |
| PRDM12PR/SET domain 12 | Often (30–79%) | In 1 condition |
| PRORPprotein only RNase P catalytic subunit | Sometimes (5–29%) | In 1 condition |
| SEPTIN9septin 9 | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 1 condition |
| COQ6coenzyme Q6, monooxygenase | Rarely (1–4%) | In 1 condition |
| LZTR1leucine zipper like post translational regulator 1 | Rarely (1–4%) | In 1 condition |
| NF2NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor | Rarely (1–4%) | In 1 condition |
| SMARCB1SWI/SNF related BAF chromatin remodeling complex subunit B1 | Rarely (1–4%) | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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