Trait
Personality disorder
A personality disorder is a deeply ingrained pattern of behavior of a specified kind that deviates markedly from the norms of generally accepted behavior. It is typically apparent by the time of adolescence and causes long-term difficulties in personal relationships or functioning in society.
Summary
- Body system
- Abnormality of the nervous system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test16 genes linked to Personality disorder
Changes in these genes cause rare conditions in which Personality disorder is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Often (30–79%) | In 1 condition |
| CHD2chromodomain helicase DNA binding protein 2 | Often (30–79%) | In 1 condition |
| CUX2cut like homeobox 2 | Often (30–79%) | In 1 condition |
| DNM1dynamin 1 | Often (30–79%) | In 1 condition |
| DRD2dopamine receptor D2 | Often (30–79%) | In 1 condition |
| GABRB3gamma-aminobutyric acid type A receptor subunit beta3 | Often (30–79%) | In 1 condition |
| KCTD17potassium channel tetramerization domain containing 17 | Often (30–79%) | In 1 condition |
| MAPK10mitogen-activated protein kinase 10 | Often (30–79%) | In 1 condition |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Often (30–79%) | In 1 condition |
| SGCEsarcoglycan epsilon | Often (30–79%) | In 1 condition |
| SPG21SPG21 abhydrolase domain containing, maspardin | Often (30–79%) | In 1 condition |
| TOR1Atorsin family 1 member A | Often (30–79%) | In 1 condition |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Sometimes (5–29%) | In 1 condition |
| KCNT1potassium sodium-activated channel subfamily T member 1 | Sometimes (5–29%) | In 1 condition |
| CBScystathionine beta-synthase | Not recorded | In 1 condition |
| XKX-linked Kx blood group antigen, Kell and VPS13A binding protein | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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