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Gene

TSEN15

tRNA splicing endonuclease subunit 15

Summary

Cytogenetic location
1q25.3
Coordinates
Chromosome 1: 184,051,730–184,074,212 (GRCh38)
Exons
5 exons across 22.5 kb
Protein
171 amino acids
Previous symbols
C1orf19
MANE Select transcript
ENST00000645668.2NM_052965.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Spinal Muscular Atrophy

    • A group of disorders characterised by degeneration of spinal cord anterior horn cells, leading to progressive muscle weakness and atrophy.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Gene therapy (onasemnogene abeparvovec), antisense oligonucleotide therapy (nusinersen), oral splicing modifier (risdiplam), supportive care

How TSEN15 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where TSEN15 sits. TSEN15 and 7 genes near it on chromosome 1, from 183,562,971 to 184,562,970.Chromosome 11q25.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44183.6 Mb183.8 Mb184 Mb184.2 Mb184.4 MbSMG7: 183,471,871–183,598,246, forward strandSMG7NCF2: 183,554,461–183,593,499, reverse strandNCF2ARPC5: 183,620,846–183,635,908, reverse strandARPC5RGL1: 183,636,066–183,928,532, forward strandRGL1APOBEC4: 183,646,275–183,653,316, reverse strandAPOBEC4COLGALT2: 183,929,854–184,037,777, reverse strandCOLGALT2TSEN15: 184,051,730–184,074,212, forward strandTSEN15C1orf21: 184,386,067–184,629,019, forward strandC1orf21Diagram of TSEN15: 5 exons on the forward strand of chromosome 1Exon 3: 1 known disease-causing siteExon 1: 184,051,730–184,051,890, 161 basesExon 2: 184,054,354–184,054,435, 82 basesExon 3: 184,054,728–184,054,863, 136 basesExon 4: 184,072,157–184,072,298, 142 basesExon 5: 184,072,827–184,074,212, 1,386 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 22.5 kb; 516 of those bases code for the protein.

How a genome test reads TSEN15

1

position in TSEN15 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 22.5 kb of TSEN15, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TSEN15 gene: tRNA splicing endonuclease subunit 15. Retrieved 16 October 2026, from https://dantelabs.com/genes/tsen15

Vancouver

Dante Labs. TSEN15 gene: tRNA splicing endonuclease subunit 15 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tsen15

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