Traits

Traits linked to TNNT2

troponin T2, cardiac type

The Human Phenotype Ontology links 50 traits to TNNT2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal ST segment	Always
Bulge in wall of large artery that carries blood away from heart	Always
Enlarged and thickened heart muscle	Always
Increased left ventricular end-diastolic volume	Always
Left axis deviation	Always
Left ventricular noncompaction	Always
Low blood pressure	Always
Reduced left ventricular ejection fraction	Always
Restrictive cardiomyopathy	Always
Right atrial enlargement	Always
Abnormal left ventricular function	Very often (80–99%)
Left ventricular systolic dysfunction	Very often (80–99%)
Stretched and thinned heart muscle	Very often (80–99%)
Abnormal heart rate	Often (30–79%)
Angina pectoris	Often (30–79%)
Cardiac failure	Often (30–79%)
Interstitial cardiac fibrosis	Often (30–79%)
Left atrial enlargement	Often (30–79%)
Pulmonary venous hypertension	Often (30–79%)
Sudden cardiac death	Often (30–79%)
Ventricular septal hypertrophy	Often (30–79%)
Complete right bundle branch block	Sometimes (5–29%)
Incomplete right bundle branch block	Sometimes (5–29%)
Left ventricular hypertrophy	Sometimes (5–29%)
Mitral regurgitation	Sometimes (5–29%)
Prolonged QT interval	Sometimes (5–29%)
Quivering upper heart chambers resulting in irregular heartbeat	Sometimes (5–29%)
Sinus bradycardia	Sometimes (5–29%)
Supraventricular arrhythmia	Sometimes (5–29%)
Tricuspid regurgitation	Sometimes (5–29%)
Fainting spell	Rarely (1–4%)
Stroke	Rarely (1–4%)

Laboratory abnormality

Trait	How often it is seen
Increased circulating brain natriuretic peptide concentration	Always
Fluid retention	Often (30–79%)
Excess fluid in lungs	Sometimes (5–29%)
Peripheral edema	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
EMG abnormality	Sometimes (5–29%)
Loss of fat tissue in localized area	Sometimes (5–29%)
Muscle tissue disease	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Exertional breathlessness	Often (30–79%)
Orthopnea	Often (30–79%)
Breathing difficulty	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Thromboembolic stroke	Sometimes (5–29%)
Thromboembolism	Rarely (1–4%)

Abnormal cellular phenotype

Trait	How often it is seen
Myocardial sarcomeric disarray	Always

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent respiratory infections	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Growth delay as children	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TNNT2 and how often each is seen. Find out more at hpo.jax.org.

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